Patients with neurosyphilis can usually have children after standardized treatment and stable condition, but they need to strictly follow medical monitoring and intervention measures. Neurosyphilis may be caused by infection of the central nervous system with Treponema pallidum, and the risk needs to be controlled through penicillin treatment, regular serological testing, cerebrospinal fluid examination, maternal and infant blockade intervention, long-term follow-up, and other methods. Patients with neurosyphilis need to undergo systematic treatment under the guidance of a professional doctor to ensure the complete removal of Treponema pallidum from their blood and cerebrospinal fluid during childbirth. Pregnancy should be avoided during treatment, and penicillin is the preferred medication. Some patients may require multiple courses of treatment. After completing treatment, it is necessary to regularly review serological indicators and cerebrospinal fluid conditions to confirm the absence of active infection before considering pregnancy planning. During pregnancy, it is necessary to strengthen prenatal check ups and reduce the risk of mother to child transmission through measures such as medication blockade and cesarean section. A small number of active patients who have not been properly controlled for their condition have a higher risk of congenital syphilis, miscarriage, or stillbirth in the fetus. If there are persistent abnormalities in cerebrospinal fluid without improvement, repeated positive serological indicators, or worsening neurological symptoms, the family planning should be temporarily suspended. These patients need to receive intensive treatment until the cerebrospinal fluid cell count returns to normal and the serological titer continues to decrease for at least one year. After multidisciplinary evaluation, fertility can be decided. Patients with neurosyphilis under family planning should undergo pre pregnancy counseling six months in advance, monthly serological tests during pregnancy, and syphilis screening of newborns after delivery. It is necessary to maintain a regular daily routine and balanced nutrition, avoid behaviors that damage the immune system such as smoking and drinking, and strictly use contraception during treatment until confirmed safe by a doctor. Any abnormal pregnancy symptoms require immediate medical attention, and combined maternal and infant follow-up should continue for at least 2 years postpartum.



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