Whether neurosyphilis patients can conceive depends on the control of their condition. If they receive standardized treatment and stable serological testing, they can usually conceive; If in an active period or not treated properly, it may cause serious harm to the fetus. Neurosyphilis is a infectious diseases caused by Treponema pallidum invading the central nervous system, which may lead to meningitis, tuberculosis, paralytic dementia and other complications. Patients with neurosyphilis who have received standardized treatment and stable serological indicators can plan pregnancy under the supervision of a doctor. Penicillin is the preferred drug for treating neurosyphilis, and through full course treatment, cerebrospinal fluid indicators can be restored to normal. Prior to pregnancy, treatment must be completed and serum rapid plasma reagin test and Treponema pallidum particle agglutination test should be regularly reviewed to ensure no active infection. During pregnancy, it is necessary to strengthen prenatal examinations and exclude congenital syphilis in the fetus through methods such as ultrasound and amniocentesis. Untreated or incompletely treated neurosyphilis patients have a higher risk of fertility. Treponema pallidum can spread vertically through the placenta, leading to miscarriage, stillbirth, or congenital syphilis. Newborns may develop conditions such as Hutchinson triad, osteochondritis, anemia, etc. Infected individuals during the active period may also have an increased risk of complications such as gestational hypertension and premature birth due to abnormal cerebrospinal fluid. In such cases, the family planning should be temporarily postponed until standardized treatment is completed and follow-up meets the standards before consideration. Patients with neurosyphilis should undergo multidisciplinary evaluation before planning pregnancy, including combined diagnosis and treatment of neurology, infectious diseases, and obstetrics. During pregnancy, serum titers need to be rechecked monthly. If there is an increase in titers, re treatment is required. If a breastfeeding mother is serological positive but has no active infection, she can breastfeed after standardized treatment. It is recommended that spouses undergo syphilis screening simultaneously to avoid repeated infections. Maintaining a regular schedule and balanced diet can help enhance immunity and avoid behaviors that damage neurological function, such as smoking and drinking.



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