neurosyphilis may be transmitted to partners through sexual contact, but the probability of transmission is lower than early syphilis. Neurosyphilis is a late stage manifestation of Treponema pallidum infection in the central nervous system, and its infectivity mainly depends on whether the patient also has active skin and mucosal damage. If patients with neurosyphilis have open skin lesions such as genital ulcers and mucosal plaques, they may transmit Treponema pallidum through fluid exchange during sexual contact. These patients should strictly avoid unprotected behavior until standardized treatment is completed and serological tests turn negative. Even without obvious skin lesions, there is still a theoretical risk of transmission through semen or vaginal secretions, but the actual probability of infection is relatively low. If the patient has received sufficient penicillin treatment and has no active skin lesions, the infectivity will be significantly reduced. However, Treponema pallidum may remain latent in the body for a long time. It is recommended to regularly review serological indicators to confirm no signs of recurrence before resuming sexual activity. Partners should undergo syphilis screening simultaneously and receive preventive treatment if necessary. Patients with neurosyphilis and their partners should take protective measures together, and using condoms during treatment can reduce the probability of transmission. Maintain a single sexual partner relationship and avoid high-risk sexual contact. Pay attention to supplementing high-quality protein and vitamins in daily life, exercise moderately to enhance immunity, and regularly check cerebrospinal fluid and serological indicators. Seek medical attention promptly when experiencing neurological symptoms such as headaches and visual abnormalities.



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