What is the reason why high blood pressure cannot be lowered

Persistent high blood pressure that cannot be lowered may be related to multiple factors such as genetics, environment, physiology, and pathology, and requires targeted adjustments to lifestyle, medication treatment, or medical screening. Genetic factors, unhealthy lifestyle habits, chronic diseases, medication effects, etc. can all lead to poor blood pressure control, and corresponding measures should be taken according to specific reasons.

1. Genetic factors: People with a family history of hypertension have a higher risk of developing the disease. Genetic factors may lead to decreased vascular elasticity or abnormal renal sodium excretion, resulting in elevated blood pressure. It is recommended to regularly monitor blood pressure, intervene early, and use antihypertensive drugs under the guidance of a doctor if necessary.

2. Environmental factors: Long term exposure to adverse environments such as high stress, high salt diet, and lack of exercise can easily lead to elevated blood pressure. High salt diet will increase the concentration of sodium ions in the body, resulting in water and sodium retention, and increase blood volume; Lack of exercise can cause a decrease in vascular elasticity and increase the burden on the heart. Suggest reducing salt intake, keeping the daily salt intake below 5 grams, and increasing aerobic exercise such as brisk walking, swimming, etc. for at least 150 minutes per week.

3. Physiological factors: As age increases, blood vessels gradually harden and the ability to regulate blood pressure decreases. Obesity, sleep apnea syndrome, and other conditions can also increase the burden on blood pressure. Obese individuals have excessive accumulation of body fat, which increases the burden on the heart; Sleep apnea can lead to nocturnal hypoxia, stimulate sympathetic nervous system excitation, and increase blood pressure. It is recommended to control weight, maintain a BMI between 18.5-24, improve sleep quality, and use ventilator assisted therapy if necessary.

4. Pathological factors: Chronic kidney disease, endocrine disorders such as hyperthyroidism, Cushing's syndrome, and other pathological conditions may lead to difficulty in controlling blood pressure. Kidney diseases can affect water and sodium metabolism, while endocrine disorders may disrupt hormone balance and lead to elevated blood pressure. It is recommended to seek medical examination and treatment for the primary disease, such as using ACEI drugs to protect kidney function, or medication or surgical treatment for endocrine disorders.

5. Drug effects: Certain drugs such as nonsteroidal anti-inflammatory drugs and steroid drugs may interfere with blood pressure control. NSAIDs can inhibit the synthesis of prostaglandins, resulting in water and sodium retention; Hormone drugs may cause water sodium retention and vasoconstriction. It is recommended to adjust medication under the guidance of a doctor to avoid long-term use of drugs that may increase blood pressure.

If high blood pressure persists and cannot be lowered, a comprehensive evaluation is needed. Adjusting lifestyle, regulating medication, and identifying underlying diseases are key to controlling blood pressure. It is recommended to regularly monitor blood pressure, record diet and exercise, communicate with doctors, develop personalized treatment plans, and conduct further examinations if necessary to clarify the cause.