What is the reason for low progesterone in gynecological endocrine examination?

gynecological endocrine examination found that low progesterone may be related to luteal insufficiency, polycystic ovary syndrome, thyroid dysfunction, hyperprolactinemia, premature ovarian failure, and other factors. Progesterone is an important hormone for maintaining pregnancy, and low levels may increase the risk of menstrual disorders, infertility, or miscarriage.

1. Luteal insufficiency

Luteal insufficiency is a common cause of low progesterone levels, which may be related to poor follicular development or shortened luteal phase. Patients may experience symptoms such as shortened menstrual cycle and premenstrual spotting. Treatment should follow the doctor's advice to supplement progesterone with progesterone capsules or dexamethasone tablets, and if necessary, combine ovulation inducing drugs such as clomiphene citrate tablets.

2. Polycystic ovary syndrome

Patients with polycystic ovary syndrome often have insufficient progesterone secretion due to ovulation disorders, accompanied by hirsutism, acne, and insulin resistance. Diagnosis requires a combination of ultrasound and hormone testing. Treatment can use ethinylestradiol and cyproterone acetate tablets to regulate the menstrual cycle, or use letrozole tablets to induce ovulation, while improving lifestyle and controlling weight.

3. Thyroid dysfunction

hypothyroidism can interfere with the hypothalamic pituitary ovarian axis function, indirectly causing a decrease in progesterone. Patients may have symptoms such as fatigue, fear of cold, and constipation. Diagnosis should be confirmed through thyroid function examination, and levothyroxine sodium tablets should be used as a substitute for treatment according to medical advice. Progesterone levels can often improve after thyroid function recovery.

4. Hyperprolactinemia

Excessive prolactin can inhibit the secretion of gonadotropins, leading to a decrease in progesterone synthesis. Common manifestations include amenorrhea and galactorrhea. Diagnosis requires testing of serum prolactin levels and magnetic resonance imaging to rule out pituitary tumors. Treatment can use bromocriptine mesylate tablets or cabergoline tablets to reduce prolactin and restore ovulation function.

5. Premature ovarian failure

Ovarian function decline before the age of 40 can lead to sustained low progesterone levels, accompanied by menopausal symptoms such as hot flashes and night sweats. Diagnosis requires testing for anti-M ü llerian hormone and follicle stimulating hormone. The treatment can use sequential therapy of estrogen and progesterone, such as estradiol valerate tablets combined with progesterone soft capsules, and fertility preservation evaluation may be performed if necessary.

If low progesterone is found, the cause should be identified through comprehensive examinations of six sex hormones, thyroid function, pelvic ultrasound, etc. Maintain a regular daily routine, avoid excessive dieting, and consume foods rich in vitamin E and Omega-3 such as nuts and deep-sea fish in moderation. If planning to conceive, it is necessary to monitor ovulation under the guidance of a doctor and supplement progesterone in a timely manner, avoiding intense exercise and mental stress. If abnormal vaginal bleeding or abdominal pain occurs, seek medical attention promptly.