Should I take hepatoprotective drugs for high indirect bilirubin?

Whether the elevation of indirect bilirubin requires the use of hepatoprotective drugs should be determined based on the specific cause. In most cases, immediate use of hepatoprotective drugs is not necessary, and in rare cases, treatment should be targeted at the primary disease. Indirect bilirubin elevation is common in non liver direct injury causes such as hemolytic diseases and Gilbert syndrome. Hemolytic diseases may lead to increased destruction of red blood cells and excessive indirect bilirubin production. In this case, treatment should be targeted at the cause of hemolysis rather than simply protecting the liver. Gilbert syndrome is a benign genetic disease that usually does not require special medication, only avoiding triggers such as hunger and infection. Both of these situations do not recommend blindly using hepatoprotective drugs, as excessive use may increase the metabolic burden on the liver. If indirect bilirubin elevation is accompanied by abnormal direct bilirubin or abnormal liver function indicators, it may indicate liver diseases such as hepatitis and bile duct obstruction. At this point, a clear diagnosis should be made through imaging and pathogen testing. Under the guidance of a doctor, liver protective drugs such as Silymarin Capsules and Compound Glycyrrhizin Tablets should be selected. At the same time, antiviral and obstructive treatments should be carried out for the primary disease. Taking liver protective drugs without professional evaluation may mask the progression of the disease.

If indirect bilirubin elevation is found, complete examinations such as blood routine, reticulocyte count, and complete liver function should be conducted to determine the cause. In daily life, it is necessary to avoid drinking alcohol, use hepatotoxic drugs with caution, and maintain a regular schedule. If the value continues to increase or symptoms such as yellow skin staining and darkened urine appear, it is necessary to seek medical attention promptly at the gastroenterology or hematology department.