Is there a relationship between high transaminase levels and fatigue

Elevated transaminase levels may be related to fatigue, but can also be caused by factors such as liver disease and drug damage. Transaminase is a sensitive indicator reflecting liver cell damage, and excessive fatigue may lead to transient elevation. In the short term, high-intensity physical labor or excessive mental stress can increase the metabolic burden of the body, which may cause changes in liver cell membrane permeability, leading to mild elevation of alanine aminotransferase and aspartate aminotransferase. This type of elevation usually returns to normal within 1-2 weeks after sufficient rest, accompanied by symptoms such as fatigue and decreased appetite. Suggest adjusting your sleep schedule to ensure 7-8 hours of sleep per day, avoiding staying up late and vigorous exercise. You can also combine foods rich in vitamin B, such as whole grains and lean meat, to help with recovery. If the transaminase continues to rise for more than 2 weeks or exceeds the normal value by more than 3 times, pathological factors should be considered. Viral hepatitis, such as hepatitis B and hepatitis C, can cause inflammation and necrosis of hepatocytes, which is characterized by a significant increase in transaminase, jaundice, and liver pain. Fatty liver patients may experience mild to moderate elevation of transaminases due to liver cell fat accumulation, which is common in obese individuals. Certain antibiotics such as isoniazid tablets and antiepileptic drugs such as sodium valproate tablets may also cause liver toxicity, leading to abnormal indicators. This type of situation requires comprehensive hepatitis virus screening, liver ultrasound, and other examinations. If necessary, liver protective drugs such as compound glycyrrhizin tablets and silymarin capsules should be used according to medical advice for treatment. Long term monitoring of changes in transaminase indicators is of great significance. It is recommended to avoid the misuse of health supplements and traditional Chinese medicine preparations with unknown ingredients, and to undergo regular liver function tests. Individuals aged 40 and above or those with risk factors for chronic liver disease should undergo at least one liver elasticity test and alpha fetoprotein screening annually. When symptoms such as yellowing of the skin and sclera, abdominal distension, etc. occur, it is necessary to seek timely medical attention from a gastroenterologist or liver disease specialist.