Is there a relationship between high transaminase levels and emotional fluctuations?

Elevated transaminase levels may be associated with emotional fluctuations, but are more common in factors such as liver disease, drug damage, or metabolic abnormalities. Emotional fluctuations may indirectly affect liver function through neuroendocrine pathways, but they are usually not the main cause. When emotions fluctuate violently, the human body releases a large amount of stress hormones such as catecholamines and cortisol, which may temporarily increase transaminase levels through the liver metabolic pathway. People who have been in a state of anxiety and depression for a long time may experience secondary behaviors such as decreased appetite and alcohol abuse, which may further affect liver function. However, the elevation of transaminase caused by such situations is mostly mild and temporary, and can generally recover on its own after emotional stability. Persistent elevation of transaminase levels requires consideration of organic diseases such as viral hepatitis, fatty liver, and drug-induced liver injury. Patients with viral hepatitis may experience symptoms such as fatigue and jaundice, and require antiviral treatment. Long term use of statins or antipyretic analgesics may cause liver cell damage, manifested as persistent abnormalities in transaminase levels. In special cases such as autoimmune liver disease, elevated transaminase levels may be accompanied by elevated globulin or positive specific antibodies.

It is recommended to rule out common liver disease factors when abnormal transaminase is detected, and maintaining a regular sleep schedule and balanced diet can help with liver function recovery. Emotional management can be used as an auxiliary tool, but professional medical examinations should not be ignored. If the transaminase continues to exceed the normal value by three times or is accompanied by other symptoms, it is necessary to seek medical attention promptly at the gastroenterology or liver disease department.