Is the two plus signs of urine protein in the physical examination serious

The discovery of two plus signs in urine protein during physical examination may indicate kidney problems, but the severity needs to be comprehensively judged in conjunction with other examinations. Positive urine protein may be related to physiological or pathological factors, and it is recommended to seek medical attention promptly to clarify the cause.

The two plus signs of urinary protein are commonly seen in physiological states such as intense exercise, fever, and cold stimulation. They are usually transient manifestations and can be restored to normal after removing the triggering factors and re examination. Some people may experience positional proteinuria after standing for a long time, which is relieved after lying down and resting. Pregnant women in the middle and late stages of pregnancy may also experience mild proteinuria due to increased renal load, which often resolves on its own after childbirth. This type of situation usually does not require special treatment, but regular monitoring of changes in urine routine is necessary.

Pathological urinary protein is common in glomerulonephritis, diabetes nephropathy, hypertensive kidney damage and other diseases. Patients with glomerulonephritis may have edema, hematuria, and elevated blood pressure, and the pathological type needs to be determined through renal biopsy. The early manifestation of diabetes nephropathy is microalbuminuria. With the progress of the disease, dominant proteinuria and renal function decline can occur. Hypertension induced renal arteriolar sclerosis can lead to sustained positive urine protein, accompanied by target organ damage such as retinal arteriosclerosis. When autoimmune diseases such as systemic lupus erythematosus involve the kidneys, in addition to proteinuria, multiple systemic symptoms such as joint pain and rash may also occur. After discovering abnormal urinary protein, it is recommended to avoid a high salt and high protein diet. Daily salt intake should be controlled within 5 grams, and protein intake should prioritize high-quality proteins such as eggs and milk. Pay attention to recording daily changes in urine output and observe for eyelid or lower limb edema. Avoid using nephrotoxic drugs such as nonsteroidal anti-inflammatory drugs, aminoglycoside antibiotics, etc. It is recommended to have a follow-up urine routine, urinary microalbumin, and renal function test every 3-6 months, and if necessary, perform a 24-hour urine protein quantification test. If accompanied by symptoms such as elevated blood pressure or edema, it is necessary to seek medical attention in the nephrology department as soon as possible to complete examinations such as urine protein electrophoresis and renal ultrasound.