Is high transaminase levels in children's physical examination caused by obesity?

A high transaminase level in children's physical examination may be related to obesity, but it may also be caused by other factors. Common causes of elevated transaminase levels include non-alcoholic fatty liver disease, viral hepatitis, drug-induced liver injury, genetic metabolic disorders, and vigorous exercise. It is recommended to conduct a comprehensive evaluation based on other examination results and seek medical attention promptly to clarify the cause.

1. Obesity related liver disease

Obese children are prone to non-alcoholic fatty liver disease, which is a common cause of elevated transaminase levels. Fat accumulation can lead to inflammation and damage of liver cells, manifested as mild elevation of alanine aminotransferase and aspartate aminotransferase. Parents need to help children control their weight by adjusting their diet and increasing exercise.

2. Viral infection

Hepatitis A, B and other viral infections can cause liver cell damage, leading to a significant increase in transaminase levels. The child may experience symptoms such as fatigue and decreased appetite. Diagnosis should be confirmed through serological testing, and if necessary, antiviral drugs such as recombinant human interferon alpha 2b injection and entecavir dispersible tablets should be used according to medical advice.

3. Drug factors

Some antibiotics, antipyretic analgesics, etc. may cause drug-induced liver injury. Improper use of drugs such as acetaminophen suspension and amoxicillin clavulanate potassium dry suspension may lead to transaminase abnormalities. Parents should avoid self administering medication to their children and strictly follow medical advice.

4. Metabolic diseases

Genetic metabolic diseases such as Wilson's disease and glycogen storage disorder can be characterized by sustained elevation of transaminases. This type of disease is often accompanied by symptoms such as abnormal ceruloplasmin and hypoglycemia. Diagnosis requires genetic testing, and treatment may require the use of specific drugs such as penicillamine tablets.

5. Physiological fluctuations

Intense exercise, high-fat diet before examination, etc. may lead to transient elevation of transaminases. It is recommended to maintain a normal daily routine and avoid strenuous activities before the re examination. If the re examination results are normal, no special treatment is required. After discovering elevated transaminase levels, parents should take their children to pediatrics or liver disease departments for comprehensive liver function, ultrasound, and other examinations. In daily life, it is necessary to maintain a balanced diet, limit the intake of high sugar and high-fat foods, and ensure sufficient sleep. Obese children should develop a scientific weight loss plan and engage in 3-5 aerobic exercises per week, such as swimming, cycling, etc. Avoid blindly using hepatoprotective drugs, all treatments should be carried out under the guidance of a doctor.