Insomnia before physical examination generally does not have a direct impact on most routine physical examination results, but may interfere with some indicators such as blood pressure and blood sugar. Insomnia is usually caused by short-term psychological stress or disrupted sleep patterns. If it persists for a long time, pathological factors such as anxiety should be investigated. Short term insomnia has a relatively small impact on basic indicators such as blood routine, liver function, and kidney function, which mainly reflect the long-term physiological state of the body. But fasting blood glucose may temporarily increase due to increased secretion of stress hormones, and systolic and diastolic blood pressure may also be higher than daily levels. In electrocardiogram examination, heart rate variability may be abnormal due to autonomic nervous system dysfunction, but it will not change the results related to cardiac structure. For examinations that require sedation and cooperation, such as gastroscopy, anxiety caused by insomnia may increase the difficulty of operation. Long term insomnia patients may experience abnormal levels of thyroid hormones and fluctuations in immune related indicators. Chronic sleep deprivation can affect the endocrine system through the hypothalamic pituitary axis, leading to disruption of cortisol circadian rhythms. Some tumor markers such as CA125 may show false positives due to inflammatory reactions, but it needs to be comprehensively judged in conjunction with other tests. Insomnia related to depression may be accompanied by changes in serotonin metabolite levels, and specialized evaluation is recommended for such situations. 48 hours before the physical examination, one should maintain a regular daily routine and avoid vigorous exercise and alcohol intake. If insomnia has occurred, you can explain the situation to the doctor for interpretation of the results. Long term insomnia patients are advised to improve polysomnography monitoring and, if necessary, undergo cognitive-behavioral therapy or medication intervention. Abnormal indicators after physical examination should be tested repeatedly based on clinical manifestations, and there is no need for excessive anxiety when a single result is abnormal.



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