Do two pairs of semi surface antibodies of hepatitis B have low titers and need to be reseeded

Whether it is necessary to reseed the two pairs of low titers of semi surface antibodies to hepatitis B should be comprehensively evaluated in combination with the antibody level and individual infection risk. When the surface antibody titer is lower than 10mIU/ml, it is usually recommended to reseed hepatitis B vaccine. If the titer is 10-100mIU/ml and there is a risk of high-risk exposure (such as medical staff, hepatitis B patient's family members), enhanced immunization can also be considered.

hepatitis B surface antibody is the key protective antibody to prevent hepatitis B virus infection, and its titer will naturally decline over time. When the detection result shows that the antibody level is lower than 10mIU/ml, the body's defense against hepatitis B virus is significantly weakened. At this time, the supplementary vaccine can effectively stimulate the immune system to generate sufficient antibodies again. Replenishment programs usually use the 0-1-6 month procedure to inoculate three doses of recombinant hepatitis B vaccine, and the antibody level needs to be rechecked 1-2 months after the completion of the whole vaccination. For high-risk groups who often contact with blood products or hepatitis B virus carriers, even if the antibody titer is at the critical value of 10-100mIU/ml, doctors may also suggest strengthening vaccination to maintain long-term protection effect. Some special populations may experience insufficient immune response. People with low immune function, such as HIV infected individuals and patients who use immunosuppressants for a long time, may experience a decrease in antibody production efficiency after vaccination. Therefore, it is necessary to increase the dosage or frequency of vaccination to improve the immune effect. Individuals with concealed hepatitis B infection or recovered from previous infection may have serological patterns of negative surface antigen but positive core antibody. In such cases, it is necessary to exclude active infection through HBV-DNA testing before deciding whether to reseed. A very small number of individuals who are allergic to vaccine ingredients or have experienced serious adverse reactions after previous vaccination should weigh the pros and cons before choosing other protective measures.

It is recommended to bring a complete two and a half test report of hepatitis B to the infection department or vaccination clinic for treatment. The doctor will develop a personalized plan according to the antibody level, occupational exposure risk and basic disease conditions. In daily life, attention should be paid to avoiding sharing razors, toothbrushes and other objects that may contact with blood. After occupational exposure or high-risk sexual behavior, a doctor should be promptly sent to assess whether it is necessary to inject hepatitis B immunoglobulin. Maintaining a regular schedule and balanced diet can help maintain immune function, but cannot replace the core protective role of vaccination.