Do elderly people with abnormal liver function need to undergo tumor marker testing

Abnormal liver function in elderly people usually requires tumor marker testing. Abnormal liver function may be related to benign diseases such as hepatitis and fatty liver, but it may also be an early manifestation of malignant tumors such as liver cancer. Tumor marker examination can help assist in differential diagnosis.

Abnormal liver function is a common clinical problem, and elderly people are more prone to this condition due to decreased metabolic function. Common liver function abnormalities include elevated transaminase levels, abnormal bilirubin levels, or protein synthesis disorders. When elderly people experience unexplained liver dysfunction, doctors often recommend improving tumor marker screening. Alpha fetoprotein is an important biomarker of primary liver cancer, and its elevated levels are closely related to hepatocellular carcinoma. Carcinoembryonic antigen has suggestive significance for liver metastasis of digestive tract tumors, while carbohydrate antigen 199 is associated with cholangiocarcinoma. The combined detection of these biomarkers can improve the early detection rate of tumors.

However, it should be noted that there is a possibility of false positives for tumor markers, and benign diseases such as chronic hepatitis and cirrhosis may also lead to mild elevation. Elevated biomarkers alone cannot diagnose tumors, and a comprehensive judgment based on imaging examinations is necessary. For elderly patients with a family history of liver cancer, long-term alcohol consumption, or chronic viral hepatitis, tumor marker testing is particularly important. Avoid vigorous exercise before examination, and fasting blood collection can reduce interference factors. If the results are abnormal, regular re examination should be conducted to observe the trend of dynamic changes. In addition to tumor markers, elderly patients with liver dysfunction also need to undergo comprehensive hepatitis virus screening, abdominal ultrasound, and other examinations. Regular daily routines should be maintained, avoiding the abuse of drugs and alcohol, and supplementing with high-quality protein and vitamins in moderation. When symptoms such as persistent fatigue, weight loss, and liver pain occur, timely medical attention should be sought, and the doctor should evaluate whether further enhanced CT or liver biopsy is needed.