Can neurosyphilis lead to pregnancy

Patients with neurosyphilis are generally not recommended to get pregnant, and the risk should be evaluated after the condition is stable and standardized treatment is completed. Neurosyphilis is a severe infection of the central nervous system caused by Treponema pallidum, which may be transmitted from mother to child or exacerbate pregnancy complications. Pregnancy during active neurosyphilis may lead to congenital syphilis in the fetus, manifested as miscarriage, stillbirth, or neonatal malformation. Treponema pallidum can infect fetuses through the placenta, especially in untreated early syphilis pregnant women with a higher probability of transmission. Immune changes during pregnancy may activate latent infections, exacerbate neurological damage, and result in headaches, visual impairment, or cognitive decline. The patient needs to complete standardized treatment with penicillin, and after confirming no active infection through cerebrospinal fluid examination, the pregnancy safety will be evaluated jointly by the infectious disease department and obstetrician. A small number of patients who have received standardized treatment and have stable conditions may consider pregnancy under continuous monitoring. These patients need to meet the conditions of continuous decrease in non-specific antibody titers detected by serological tests and normal cerebrospinal fluid cell counts. During pregnancy, serological indicators need to be rechecked monthly, and newborns need to undergo syphilis screening and preventive treatment after delivery. breastfeeding is usually not restricted, but if the mother has nipple damage, breastfeeding should be suspended. Patients with neurosyphilis who plan to conceive should undergo multidisciplinary consultation in advance, and strictly follow up on serological and neurological symptoms during pregnancy. It is recommended to supplement folic acid and avoid smoking and drinking alcohol. Maintaining sufficient sleep can help with immune regulation. After childbirth, it is necessary to continue monitoring the health status of the mother and baby. Newborns who experience symptoms such as fever and rash should seek medical attention promptly.