Can high total bilirubin lead to jaundice on the skin?

High total bilirubin can lead to jaundice on the skin. Total bilirubin is the sum of bilirubin, and when its concentration in the blood exceeds a certain range, it can cause jaundice in tissues such as the skin and mucous membranes. The main reasons for high total bilirubin include liver disease, biliary obstruction, and excessive destruction of red blood cells. Liver diseases such as hepatitis and cirrhosis can affect the metabolism and excretion of bilirubin, leading to an increase in total bilirubin levels in the blood. Biliary obstruction, such as gallstones and bile duct stenosis, can obstruct the discharge of bile and prevent the normal excretion of bilirubin into the intestine, leading to the accumulation of bilirubin in the blood. Excessive destruction of red blood cells, such as hemolytic anemia, can lead to the breakdown of a large amount of hemoglobin into indirect bilirubin. When it exceeds the processing capacity of the liver, it can also cause an increase in total bilirubin. Jaundice caused by high total bilirubin mainly manifests as yellowing of the skin, sclera, mucosa, and other areas. Urine color may darken to a brown color, and stool color may become lighter to a clay color. After identifying the cause, targeted treatment is needed, such as liver protection treatment for liver disease patients and relief of obstruction for biliary obstruction patients. At the same time, maintain a regular daily routine, avoid overexertion, have a light and easily digestible diet, limit intake of high-fat foods, increase intake of vitamins and dietary fiber appropriately, and maintain water and electrolyte balance.