Mild elevation of transaminase after staying up late can usually recover on its own. If the elevation persists or is accompanied by other symptoms, medical attention should be sought. Elevated transaminase levels may be related to factors such as increased liver burden and transient liver injury. Staying up late can increase the metabolic burden on the liver, especially when there is long-term sleep deprivation. The efficiency of the liver in decomposing toxins and metabolic waste decreases, which may cause a slight increase in transaminase levels. In this case, by adjusting daily routines, ensuring sufficient sleep, replenishing fluids, and eating a light diet, the indicators gradually return to normal within 1-2 weeks. Moderate intake of foods rich in vitamin B, such as oats and lean meat, can help with liver repair. If the transaminase continues to exceed the normal value by more than twice or is accompanied by symptoms such as fatigue, decreased appetite, jaundice, etc., it may indicate pathological factors such as viral hepatitis, fatty liver, drug-induced liver injury, etc. Long term staying up late combined with alcohol intake, high-fat diet and other behaviors can accelerate liver cell damage. At this time, it is necessary to improve hepatitis virus screening, liver ultrasound and other examinations. Patients with hepatitis B are more likely to have abnormal liver function after staying up late, and it is necessary to strictly avoid inducing factors.

It is recommended to avoid staying up late continuously, stop using electronic devices 2 hours before bedtime, and create a dark and quiet sleeping environment. It is advisable to consume antioxidant foods such as goji berries and blueberries in daily life to avoid overuse of liver protection and health products. If there is no decrease in transaminase levels or symptoms such as skin itching and darkened urine color after adjusting lifestyle, it is necessary to seek medical attention promptly at a gastroenterology or liver disease department.


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