Delusions of persecution usually do not heal on their own and are a mental disorder that requires professional intervention. Persecutive delusions may be related to genetic factors, abnormal brain structure, psychological trauma, long-term stress, schizophrenia, and other factors, manifested as a persistent belief in the delusional notion of being persecuted. Patients with paranoid ideation often have abnormal neurotransmitter function in their brains, and excessive activity of the dopamine system may lead to the solidification of delusional symptoms. Some patients may experience delusions due to childhood abuse or major traumatic events, and this pathological memory reconstruction is difficult to resolve on its own. The paranoid ideation associated with schizophrenia is related to functional damage to the prefrontal cortex, which is difficult to alleviate without antipsychotic medication. A small number of patients with transient delusional disorder may experience symptom relief after the stressor is eliminated, but the probability of spontaneous relief of true paranoid ideation is extremely low. Even if symptoms temporarily alleviate, patients still have a risk of recurrence, especially when experiencing stress events or discontinuing medication. Organic delusions caused by cerebrovascular disease in some elderly patients may worsen with the worsening of underlying diseases. Patients with paranoid ideation should receive systematic treatment under the guidance of a psychiatrist, and medication combined with psychological therapy can effectively control symptoms. Family members should avoid arguing with patients about delusional content, maintain a stable environment to reduce stimulation, and regularly follow up to adjust treatment plans. Establishing regular sleep habits, conducting appropriate relaxation training, and avoiding the intake of psychoactive substances such as alcohol can help assist in treatment.



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