The eosinophil count of 0.00 × 10 ⁹/L may be caused by physiological fluctuations, drug effects, infectious diseases, endocrine disorders or blood system diseases, and it needs to be comprehensively judged in combination with clinical manifestations and other examinations.
1. Physiological fluctuations: The eosinophils of healthy individuals exhibit natural fluctuations throughout the day, with lower levels in the morning and higher levels at night. Intense exercise, stress state, or pregnancy may also lead to temporary decline, usually without accompanying symptoms and can be restored to normal after re examination.
2. Drug effects:
Corticosteroid drugs such as prednisone and dexamethasone can inhibit the release of eosinophils from the bone marrow, while beta agonists such as salbutamol and some antibiotics may also cause a decrease in values. After stopping the medication, it can usually recover on its own within 1-2 weeks.
3. Acute infection: During bacterial or viral infections, the body's stress response can cause eosinophils to migrate to the site of inflammation, leading to a decrease in peripheral blood test values. Often accompanied by symptoms such as fever and cough, inflammatory indicators such as C-reactive protein often increase.
4. Endocrine disorders:
Cushing's syndrome, hyperthyroidism, and other diseases affect granulocyte distribution through abnormal hormone secretion. It may be accompanied by symptoms such as centripetal obesity and palpitations, and should be diagnosed through cortisol testing and thyroid function examination. 5. Hematological system abnormalities: Diseases such as aplastic anemia and myelodysplastic syndrome may cause a decrease in whole blood cells. Usually accompanied by anemia and bleeding tendency, a bone marrow puncture examination is needed to confirm the diagnosis.
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