What medicine to take for high uric acid? It's fast and effective

Uric acid can be effectively controlled by drugs such as allopurinol, febuxostat, and benzbromarone. Specific medication should be evaluated based on uric acid levels, renal function, and comorbidities. There are two main types of uric acid lowering drugs: those that inhibit uric acid production and those that promote uric acid excretion. They usually need to be combined with a low purine diet and lifestyle adjustments.

1. Allopurinol:

Allopurinol is a xanthine oxidase inhibitor that reduces blood uric acid concentration by blocking uric acid production. Suitable for patients with primary or secondary hyperuricemia, especially those with concomitant renal dysfunction who require dose adjustment. During medication, liver function and hypersensitivity reactions need to be monitored, and some individuals may experience adverse reactions such as rash.

2. Febuxostat:

Febuxostat is a novel selective xanthine oxidase inhibitor with a stronger uric acid lowering effect than allopurinol. Suitable for patients with recurrent gout attacks or the presence of gout stones, there is no need to adjust the dosage for patients with mild to moderate renal insufficiency. Attention should be paid to cardiovascular disease risk assessment and long-term high-dose use should be avoided.

3. Benzbromarone:

Benzbromarone promotes excretion by inhibiting renal tubular uric acid reabsorption and is suitable for patients with reduced uric acid excretion. During medication, it is necessary to ensure a daily water intake of at least 2000 milliliters, and patients with kidney stones should use it with caution. Regular monitoring of urate crystals and changes in renal function is required.

4. Combination therapy:

For refractory hyperuricemia, the combination of allopurinol and benzbromarone can be considered. The joint plan must strictly follow the doctor's advice to avoid a sudden drop in uric acid levels causing metastatic gout attacks. Patients with hypertension or diabetes should pay attention to drug interaction.

5. Adjuvant drugs:

During acute gout attacks, colchicine or nonsteroidal anti-inflammatory drugs can be used in combination to alleviate symptoms. Sodium bicarbonate can be used to alkalize urine and prevent stones, but long-term use may cause electrolyte imbalance. All medication use must be carried out under the guidance of a rheumatologist and immunologist.

In addition to medication treatment, daily water intake should be maintained at 2000-3000 milliliters to promote uric acid excretion and limit the intake of high purine foods such as animal organs and seafood. It is recommended to choose low-fat dairy products, fresh vegetables and other alkaline foods, and engage in moderate aerobic exercise such as swimming and cycling to control weight. Avoid sudden exposure to cold or intense exercise that may trigger gout, and regularly check blood uric acid and urine routine. Those with hypertension, diabetes and other basic diseases need to control metabolic indicators synchronously and establish long-term follow-up management plan.