What medicine is the fastest to lower blood lipids when triglycerides are high

Elevated triglycerides can be rapidly reduced by using beta, niacin, or statins for lipid-lowering. Commonly used drugs include fenofibrate, acyclovir, atorvastatin, etc. Drug selection should be based on a comprehensive assessment of blood lipid abnormalities, underlying diseases, and liver and kidney function. Those with severe elevation should be alert to the risk of acute pancreatitis.

1. Betrate drugs:

Fenofibrate enhances lipoprotein lipase activity by activating PPAR - α receptors and can reduce triglycerides by 30% -50%. Jifenozil has a significant effect on mixed hyperlipidemia, but caution should be exercised about the risk of rhabdomyolysis when used in combination with statins. Benzafibrate is suitable for patients with diabetes and hypertriglyceridemia, and liver function should be monitored.

2. Niacin drugs:

Axiolimus, as a sustained-release formulation, can reduce skin flushing side effects, lower triglycerides by 20% -40%, and increase high-density lipoprotein. Niacin sustained-release tablets should start from small doses, and caution should be exercised when combined with statins to avoid the risk of myopathy. Long term use requires monitoring of blood glucose and uric acid levels.

3. Statins:

Atorvastatin has a moderate triglyceride lowering effect when used in high doses and is suitable for patients with concomitant elevation of low-density lipoprotein. Rosuvastatin is effective in treating familial hypertriglyceridemia, but severe elevation requires combination therapy with beta drugs. Regular monitoring of creatine kinase is required during medication.

4. Omega-3 fatty acids:

High purity EPA ethyl ester can reduce triglycerides by 20% -30%, especially suitable for statin intolerant patients. A daily intake of at least 4g is required for significant therapeutic effects, and common dosage forms include ethyl eicosapentaenoic acid. It should be noted that co administration with anticoagulants may increase the risk of bleeding.

5. Traditional Chinese Medicine Preparations:

Xuezhikang contains natural lovastatin, which can assist in lowering cholesterol and is suitable for patients with mild elevation. Ginkgo biloba extract helps regulate blood lipid metabolism by improving microcirculation. Attention should be paid to the interaction between traditional Chinese medicine and Western medicine, and it is not recommended to use it alone for severe hypertriglyceridemia. During drug treatment, it is necessary to strictly follow a low-fat diet, control cooking oil below 25g per day, and avoid intake of refined sugar and alcohol. Engage in aerobic exercise for at least 150 minutes per week, such as brisk walking, swimming, etc. People with obesity need to lose 5% -10% weight, and diabetes patients should strengthen blood sugar control. Regularly check blood lipids, liver and kidney function, and seek medical attention immediately if muscle pain or jaundice occurs. Betrate drugs are contraindicated for pregnant women and patients with severe liver disease, and niacin preparations should be used with caution for gout patients.