What medicine is best and quickest to take for high uric acid

Patients with high uric acid levels can use medications such as febuxostat tablets, benzbromarone tablets, allopurinol tablets, sodium bicarbonate tablets, colchicine tablets, etc. under the guidance of a doctor to control their condition. Elevated uric acid may be related to factors such as abnormal purine metabolism and decreased renal function. It is necessary to choose uric acid lowering or excretion promoting drugs based on specific causes, and be alert to adverse drug reactions.

1. Febuxostat Tablets

Febuxostat tablets reduce uric acid production by inhibiting xanthine oxidase and are suitable for patients with long-term gout or hyperuricemia. This medication may cause liver dysfunction, and transaminase monitoring should be conducted regularly during the medication period. When used in combination with nonsteroidal anti-inflammatory drugs, it can reduce the risk of acute gout attacks.

II. Benzbromarone tablets

Benzbromarone tablets promote excretion by inhibiting renal tubular uric acid reabsorption and are suitable for patients with uric acid excretion disorders. During the medication period, it is necessary to drink more than 2000 milliliters of water per day to prevent urinary tract crystallization. Patients with severe kidney stones should use with caution as they may experience adverse reactions such as gastrointestinal discomfort or rash.

III. Allopurinol Tablets

Allopurinol tablets competitively inhibit xanthine oxidase to reduce blood uric acid concentration, especially suitable for patients with kidney stones. Some individuals may develop hypersensitivity reaction syndrome, and initial medication should start at low doses. The dosage needs to be adjusted when combined with azathioprine.

4. Sodium Bicarbonate Tablets

Sodium bicarbonate tablets increase the solubility of uric acid by alkalizing urine and are often used as adjunctive drugs in combination with excretion promoting drugs. Long term use may cause metabolic alkalosis or edema, and caution should be exercised for those with heart failure. During medication, it is necessary to monitor the urine pH value to maintain it between 6.2-6.9.

V. Colchicine Tablets

Colchicine tablets are mainly used for anti-inflammatory and analgesic purposes during acute gout attacks. Although they do not directly lower uric acid, they can prevent crystal pain. Common gastrointestinal reactions such as diarrhea are prohibited for patients with bone marrow suppression. When used in combination with CYP3A4 inhibitors, dosage should be reduced to avoid toxicity. In addition to standardized medication, patients with high uric acid should strictly limit high purine foods such as animal organs and seafood, and maintain a daily water intake of 2000-3000 milliliters to promote metabolism. It is recommended to choose low-intensity aerobic exercise such as swimming or cycling to avoid joint symptoms caused by intense exercise. Regularly check blood uric acid and renal function indicators. If joint redness, swelling, heat and pain occur, seek timely medical attention from the rheumatology and immunology department. Establishing a long-term management plan is more important than pursuing rapid uric acid reduction, as a sudden and significant decrease in blood uric acid levels may trigger gout attacks.