What is the standard value of uric acid within the normal range

The normal range of uric acid in adult males is 208-428 μ mol/L, and in females it is 155-357 μ mol/L. Uric acid levels are influenced by factors such as gender, age, dietary habits, metabolic status, and testing methods.

1. Gender differences:

Male uric acid levels are generally higher than females, mainly due to the inhibition of renal excretion of uric acid by androgens. After menopause, estrogen levels decrease and uric acid levels may approach the range of men. Pregnant women often have uric acid levels lower than the standard for ordinary women due to physiological blood dilution.

2. Age factor:

Uric acid levels in childhood are usually 120-330 μ mol/L, gradually approaching adult standards after puberty. The upper limit of normal value can be appropriately relaxed by 10-20 μ mol/L for middle-aged and elderly people due to renal dysfunction and decreased uric acid excretion ability.

3. Detection method:

Enzyme colorimetric method is currently the mainstream detection method, and different medical institutions' reagents may have ± 15 μ mol/L errors. Before blood collection, fasting for 8 hours is necessary to avoid vigorous exercise, otherwise it may cause a false increase of 50-100 μ mol/L in the test value.

4. Dietary effects:

A high purine diet can increase uric acid levels by 30-50 μ mol/L in the short term, and long-term intake of seafood, animal organs, and other foods may continue to raise baseline values. Drinking less than 1500ml of water per day can reduce the efficiency of uric acid excretion.

5. Pathological fluctuations:

During gout attacks, uric acid levels often exceed 500 μ mol/L, while those with renal dysfunction may continue to exceed 600 μ mol/L. The use of certain diuretics and immunosuppressants can cause drug-induced uric acid elevation.

It is recommended to regularly monitor uric acid levels, maintain a daily water intake of at least 2000ml, and limit daily purine intake to no more than 300mg. Low fat dairy products, fresh fruits and vegetables, and other alkaline foods can be chosen to help eliminate uric acid and avoid sudden intense exercise that can cause uric acid crystallization in joint synovial fluid. When uric acid levels continue to exceed 420 μ mol/L in males or 360 μ mol/L in females during physical examination, further tests such as kidney function and urine routine should be performed.