What is the significance of growth hormone stimulation test

The growth hormone stimulation test is mainly used to diagnose growth hormone deficiency in children, evaluate the functional status of pituitary secretion of growth hormone, and provide key basis for the diagnosis of the etiology of dwarfism. The growth hormone stimulation test induces the release of growth hormone from the pituitary gland through drug stimulation or physiological means, and measures the peak level of growth hormone in the blood. Experiments usually choose a combination of two drugs with different mechanisms of action, such as insulin hypoglycemia test combined with arginine stimulation test, which can improve detection accuracy. Multiple blood samples need to be collected during the experiment to monitor changes in growth hormone concentration and draw secretion curves. Healthy children can have a peak growth hormone level exceeding 10 micrograms per liter after stimulation. If the peak level is below 5 micrograms per liter, it indicates growth hormone deficiency. This experiment can distinguish between complete deficiency and partial deficiency, and has differential value for idiopathic short stature and growth hormone deficiency.

Before the experiment, it is necessary to fast for at least 8 hours and avoid vigorous exercise. Some children may experience hypoglycemic reactions, manifested as sweating, palpitations, and other symptoms. Medical staff will handle them promptly. During the trial, close monitoring of blood glucose and vital signs is necessary to ensure safety. For patients suspected of central precocious puberty, post cranial radiation therapy, or pituitary lesions, this test can evaluate the function of the hypothalamic pituitary growth hormone axis. The results need to be comprehensively judged based on indicators such as bone age and insulin-like growth factor 1 to avoid the limitations of a single experiment. After being diagnosed with growth hormone deficiency, doctors will develop a recombinant human growth hormone replacement therapy plan based on the specific situation of the child. Regularly review indicators such as growth rate, thyroid function, and blood sugar, and adjust medication dosage. Ensuring sufficient sleep and balanced nutrition in daily life, and engaging in vertical exercises such as skipping rope and basketball appropriately, can help unleash growth potential. Parents need to record their growth curve, measure their height and weight every 3 months, and promptly follow up if any abnormalities are found.