What is the reason for the low average width of red blood cells

The low average width of red blood cells may be related to factors such as iron deficiency anemia, thalassemia, chronic disease anemia, sideroblastic anemia, vitamin B6 deficiency, etc. It needs to be comprehensively judged based on other indicators of blood routine and clinical manifestations. The average width of red blood cells reflects the degree of difference in red blood cell volume size, and a lower value indicates a more uniform red blood cell size.

1. Iron deficiency anemia

Long term insufficient iron intake or absorption disorders can lead to reduced hemoglobin synthesis, small and uniform red blood cell volume. Patients may experience symptoms such as fatigue, dizziness, and brittle nails. Iron supplements such as dextran iron oral solution, protein succinate iron oral solution, and polysaccharide iron complex capsules can be taken according to medical advice, while increasing iron rich foods such as animal liver and red meat.

2. Mediterranean anemia

is a hereditary anemia caused by impaired synthesis of globin peptide chains, with generally small red blood cell volume and uniform morphology. Mild patients may be asymptomatic, while severe cases may be accompanied by jaundice and splenomegaly. Diagnosis should be confirmed through genetic testing, and if necessary, blood transfusion or iron removal therapy should be performed to avoid the use of iron supplements.

3. Chronic disease anemia

Chronic infections, inflammation, or tumors can lead to abnormal iron metabolism, and although there is sufficient iron reserve in the body, its utilization is hindered. The typical manifestation is normal or small red blood cell volume and concentrated distribution. The primary disease needs to be treated, and in severe cases, recombinant human erythropoietin injection can be used according to medical advice.

4. Iron particle anemia

Heme synthesis disorders lead to an increase in iron particle count in the bone marrow and the appearance of a large number of small cells in peripheral blood. The patient may have symptoms such as pale skin and mucous membranes, decreased appetite, etc. Vitamin B6 tablets can be tried for treatment, and some patients may require blood transfusion support.

5. Vitamin B6 deficiency

Vitamin B6 is involved in heme synthesis, and deficiency can lead to abnormal red blood cell production. May be accompanied by symptoms such as glossitis and dry lips. It can be improved by supplementing with vitamin B6 tablets, while increasing the intake of foods rich in vitamin B6 such as poultry, fish, and bananas. When the average width of red blood cells is found to be low, it is recommended to improve the detection of serum iron, ferritin, vitamin B12, etc. to clarify the cause. Pay attention to a balanced diet in daily life, ensuring intake of red meat, dark vegetables, and citrus fruits. To avoid long-term consumption of strong tea or coffee affecting iron absorption, an iron pot can be used for cooking. Moderate aerobic exercise such as jogging and swimming can promote blood circulation, but when anemia symptoms are obvious, vigorous exercise should be reduced. Regularly review changes in blood routine monitoring indicators, and seek medical attention promptly if palpitations or worsening shortness of breath occur.