What is the reason for high levels of urea nitrogen and creatinine

Elevated levels of urea nitrogen and creatinine may be caused by physiological dehydration, high protein diet, vigorous exercise, decreased kidney function, urinary tract obstruction, and other factors. They can be improved through dietary adjustments, hydration, medication treatment, dialysis intervention, and other methods.

1. Physiological dehydration:

Insufficient water intake or excessive sweating in the short term can lead to blood concentration and relative increase in urea nitrogen and creatinine concentrations. Commonly seen in situations such as high-temperature operations and failure to replenish water in a timely manner after exercise. Increasing water intake by 2000-3000 milliliters per day can usually restore normal levels within 24-48 hours.

2. High protein diet:

Excessive intake of protein rich foods such as meat, eggs, and milk can increase nitrogen metabolites, leading to an increase in urea nitrogen levels. It is recommended to control the daily protein intake at 1-1.2 grams per kilogram of body weight, prioritize high-quality protein such as fish and soy products, and pair them with sufficient vegetables and fruits to promote metabolism.

3. Intense exercise:

High intensity anaerobic exercise produces a large amount of creatine metabolites, leading to a temporary increase in creatinine. Athletes or fitness enthusiasts may experience this phenomenon, and it is recommended to supplement electrolyte drinks after exercise. After 48 hours of re examination, the indicators may fall back on their own.

4. Renal function decline:

Chronic kidney disease, diabetes nephropathy and other diseases will lead to the decline of glomerular filtration rate, and the excretion of urea nitrogen and creatinine will be blocked. It may be accompanied by symptoms such as increased nocturia and lower limb edema, and further diagnosis should be made through examinations such as urinary microalbumin and glomerular filtration rate.

5. Urinary tract obstruction: When urinary disorders are caused by diseases such as kidney stones and prostate hyperplasia, metabolic waste cannot be discharged normally. This type of situation is often accompanied by symptoms such as painful urination and fine urine flow, and the location of obstruction needs to be determined through ultrasound or CT examination. After discovering abnormal indicators, fasting blood tests should be continuously monitored for 3 days in the morning to avoid single test errors. Maintain a low salt and low-fat diet in daily life, limit daily sodium intake to no more than 5 grams, and consume water beneficial foods such as winter melon and Job's tears in moderation. Engage in 3-5 aerobic exercises per week, such as brisk walking and swimming, for at least 30 minutes each time to promote blood circulation. Patients with hypertension or diabetes need to strictly monitor blood pressure and blood sugar, and regularly review three aspects of renal function. If the indicators continue to increase or are accompanied by severe swelling, nausea, and other symptoms, it is necessary to seek timely medical attention from the nephrology department to assess whether blood purification treatment is needed.