What is the reason for high levels of female fibrinogen

The high level of female fibrinogen may be related to the physiological changes during pregnancy, inflammatory reaction, diabetes, liver diseases, malignant tumors and other factors. Fibrinogen is an important component of the coagulation system, and its elevated levels may indicate abnormal coagulation status or potential disease risk in the body.

1. Physiological changes during pregnancy

Fibrinogen levels in women in the middle and late stages of pregnancy can increase physiologically, mainly related to the promotion of liver synthesis by increased estrogen levels. This elevation usually does not require special treatment, but regular monitoring of coagulation function is necessary. After about 6 weeks postpartum, most people can gradually recover to the normal range.

2. Inflammatory response

Acute infections or chronic inflammatory diseases such as rheumatoid arthritis may lead to elevated fibrinogen levels. Inflammatory factors can stimulate the liver to accelerate the synthesis of fibrinogen, which may be accompanied by symptoms such as fever and elevated C-reactive protein. Controlling primary infection or inflammation can improve many indicators.

3. diabetes

Fibrinogen is commonly elevated in diabetes patients with long-term poor glycemic control, which is related to the accumulation of advanced glycation end products and vascular endothelial damage. The patient may have increased blood viscosity at the same time and requires intervention with hypoglycemic therapy and antiplatelet drugs such as aspirin enteric coated tablets.

4. Liver disease

Chronic hepatitis or cirrhosis may have compensatory increases in fibrinogen in the early stages, but it may decrease in the late stages of liver failure. These patients usually have liver function indicators such as abnormal transaminase and decreased albumin, and need to be regulated through liver protection treatments such as compound glycyrrhizin tablets.

5. Malignant Tumors

Some gynecological tumors, such as ovarian cancer, can secrete procoagulant substances that cause an increase in fibrinogen, which often persists and progresses rapidly. The patient may have abnormal tumor markers such as CA125, and targeted treatment such as surgery or chemotherapy should be taken after diagnosis through pathological examination. When fibrinogen is found to be high, it should be judged comprehensively based on other coagulation indicators and clinical manifestations. It is recommended to avoid high-fat diets, increase water intake in moderation, and engage in regular aerobic exercise to improve blood circulation. If there are persistent abnormalities, further examinations such as tumor screening and autoimmune antibody testing should be carried out. If necessary, anticoagulant drugs such as low molecular weight heparin calcium injection should be used for intervention under the guidance of hematologists or relevant specialists.