What is the normal range of uric acid

The normal range of blood uric acid in adult males is 149-416 μ mol/L, and in females it is 89-357 μ mol/L. Uric acid levels are influenced by various factors such as gender, age, dietary structure, metabolic status, and medication.

1. Gender differences:

Male uric acid levels are generally higher than females, which is related to the physiological mechanism of androgen promoting uric acid synthesis and estrogen inhibiting uric acid reabsorption. Postmenopausal women's uric acid levels will gradually approach the reference range for men.

2. Age factor:

Uric acid levels in childhood are usually below 200 μ mol/L and gradually increase after puberty. Due to renal dysfunction and decreased uric acid excretion ability in middle-aged and elderly populations, the normal upper limit can be relaxed by 10-20 μ mol/L.

3. Dietary effects:

A high purine diet can cause a short-term increase of 30-50 μ mol/L in uric acid. Animal organs, seafood, thick meat soup and other foods contain high purines, and vegetarians usually have uric acid levels at the lower limit of the range.

4. Detection method:

Enzyme detection is currently the mainstream method, and differences in equipment among different medical institutions may result in fluctuations of up to 5% in the results. Before blood collection, fasting for 8 hours is required to avoid intense exercise that may interfere with the accuracy of the test.

5. Pathological threshold: If

exceeds 420 μ mol/L for males or 360 μ mol/L for females, it is considered hyperuricemia. asymptomatic individuals do not require medication intervention, and treatment should be initiated when combined with gouty stones or kidney stones.

To maintain normal uric acid, daily purine intake should be controlled below 300mg, and it is recommended to increase intake of low-fat dairy products and fresh fruits and vegetables. Drink at least 2000ml of water daily to promote excretion and avoid uric acid fluctuations caused by excessive dieting or vigorous exercise. Weight loss in obese individuals can significantly reduce uric acid levels, but rapid weight loss should be avoided to prevent uric acid rebound elevation. Regular monitoring of uric acid is of great significance in preventing gout attacks and renal dysfunction.