Paranoia is a mental disorder in which patients have an unfounded belief that they are being persecuted or harmed by others. Paranoia may be caused by genetic factors, abnormal brain structure, psychological trauma, drug abuse, schizophrenia, and other factors.

1. Genetic factors
Persecutive delusions have a certain degree of familial clustering, and individuals with a history of mental illness in their immediate family members have a higher probability of developing the disease. These patients usually require long-term psychological intervention and medication assisted treatment, and early identification of family medical history can help prevent disease development.
2. Structural abnormalities in the brain
Functional abnormalities in the prefrontal and temporal lobes of the brain may lead to the development of paranoid ideation, which are responsible for logical judgment and reality testing. Brain scanning technology can detect relevant abnormalities, and targeted cognitive training can improve some symptoms.
3. Psychological trauma
Childhood experiences of abuse, violence, and other traumatic events can easily form a victim psychological pattern. Patients with post-traumatic stress disorder may experience temporary delusions of persecution, and psychological therapy should focus on dealing with traumatic memory.

4. Drug abuse
Long term use of amphetamine type drugs or excessive alcohol consumption may trigger paranoid ideation. These substances can interfere with the function of the dopamine system and alleviate symptoms after withdrawal, but some patients may develop persistent disorders.
5. Schizophrenia
Delusions of persecution are one of the typical symptoms of schizophrenia, often accompanied by hallucinations and thinking disorders. Antipsychotic drugs such as risperidone, olanzapine, and quetiapine can control symptoms and require social functional rehabilitation training.

Delusions of persecution require systematic evaluation and treatment by professional psychiatrists. Family members should maintain patient communication, avoid arguing with patients about delusional content, regularly accompany patients for follow-up visits, and supervise medication. Establishing a regular daily routine, reducing caffeine intake, and participating in moderate group activities can help improve symptoms. During the stable period of the condition, psychological adjustment methods such as mindfulness meditation can be attempted, but medical attention should be sought immediately when acute symptoms occur.
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