Persecutive delusions is a mental disorder that belongs to a subtype of delusional disorders. It is mainly characterized by patients firmly believing that they are being persecuted, monitored, or treated in a conspiracy, even if there is a lack of objective evidence. Paranoia may be caused by genetic factors, abnormal brain structure, psychological trauma, long-term stress, substance abuse, and other reasons. Patients typically exhibit symptoms such as excessive alertness, distrust of others, and repeated complaints about their experiences of victimization, which may be accompanied by social withdrawal or aggressive behavior in severe cases.

1. Genetic factors
Some patients with paranoid ideation have a familial genetic tendency, and studies have shown that specific gene variations may increase the probability of developing the disease. These patients have an earlier onset age and often have more stubborn symptoms. People with a history of schizophrenia or delusions among relatives should be vigilant, but genetics is not the determining factor, and environmental intervention can still effectively alleviate symptoms.
2. Brain structural abnormalities
Neuroimaging has found that some patients have functional abnormalities in the temporal and prefrontal regions of the brain, and imbalances in neurotransmitters such as dopamine may lead to information processing deviations. These physiological changes can lead patients to misinterpret neutral events as threatening signals, forming stubborn erroneous beliefs. Early brain function training may help improve cognitive function.
3. Psychological trauma
Childhood experiences of abuse, violent injury, or long-term bullying may trigger a sense of victimization. Patients reconstruct reality through delusions to cope with indigestible painful experiences, forming pathological psychological defense mechanisms. Psychological therapy for trauma combined with stable interpersonal support can help rebuild a sense of security.

4. Long term stress
Continuous work pressure, family conflicts, or social adaptation difficulties may lead to cognitive resource depletion, making people tend to use simplified victim logic to explain complex situations. This type of situation is common in the middle-aged population, and stress management training and cognitive-behavioral therapy can significantly improve symptoms.
5. Substance abuse
Long term abuse of amphetamine type drugs and alcohol can directly damage the brain's judgment function and induce transient delusions. The side effects of some prescription drugs may also lead to similar symptoms. Timely withdrawal of addictive substances and combined with nutritional nerve therapy can gradually alleviate the symptoms of most patients.

The diagnosis of paranoid ideation requires professional evaluation by a psychiatrist, and treatment usually combines antipsychotic drugs with psychological intervention. Family members should avoid arguing with patients about delusional content and instead focus on their emotional needs, establishing a regular living environment. Maintaining moderate social activity and a balanced diet can help stabilize nervous system function, and Omega-3 fatty acids and B vitamins may have a supportive effect on brain metabolism. During the rehabilitation period, patients need to have regular follow-up visits to gradually reduce excessive attention to threat signals and rebuild their ability to test reality.
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