What is high creatine kinase isoenzyme

Elevated creatine kinase isoenzyme may be caused by myocardial injury, skeletal muscle lesions, intense exercise, drug effects, or hypothyroidism, and should be judged comprehensively based on clinical symptoms and other examinations.

1. Myocardial injury: When myocardial cells are damaged, creatine kinase isoenzyme is released, and acute myocardial infarction is the most typical cause. Patients often experience chest pain and ST segment elevation on electrocardiogram, requiring urgent coronary angiography and dynamic monitoring of myocardial enzyme spectrum. Mild myocarditis may also cause abnormalities in this indicator, manifested as palpitations or shortness of breath after activity.

2. Skeletal muscle lesions:

Progressive muscular dystrophy, polymyositis, and other diseases can cause muscle fiber damage and release large amounts of creatine kinase isoenzymes. The patient may experience symmetrical muscle weakness and muscle pain symptoms, with electromyography showing myogenic damage. In some cases, diagnosis may require muscle biopsy. 3. Intense exercise: Within 24-48 hours after high-intensity anaerobic exercise, there may be a temporary increase in indicators, especially common among marathon runners or strength trainers. This physiological elevation usually does not exceed three times the normal value and recovers on its own after 72 hours of rest, without the need for special treatment.

4. Drug effects:

Statins as lipid-lowering drugs may cause drug-induced myositis, leading to abnormal indicators and clinical manifestations of muscle pain accompanied by elevated creatine kinase. Partial anesthetics or immunosuppressants may also interfere with the test results, which gradually return to normal 2-4 weeks after discontinuation.

5. Hypothyroidism:

Thyroid hormone deficiency can reduce the metabolic capacity of muscle cells and cause muscle enzyme exudation. Patients often have symptoms such as fatigue, chills, and myxoedema. Supplementing with levothyroxine sodium can improve abnormal indicators.

found that when creatine kinase isoenzyme is elevated, vigorous exercise should be avoided, red meat and high purine food intake should be reduced, and 2000 milliliters of water per day should be ensured to promote metabolism. It is recommended to improve the examination of troponin, thyroid function, electromyography, etc. Middle aged and elderly patients should focus on screening for cardiovascular diseases. Pregnant women with abnormal indicators should rule out pregnancy related myocardial injury, and pediatric patients should be alert to the possibility of hereditary myopathy. Regularly reviewing the trend of indicator changes is more clinically significant than a single test value.