Emotional instability personality disorder is a mental disorder characterized by intense emotional fluctuations, tense interpersonal relationships, and impulsive behavior. It mainly includes two subtypes: borderline personality disorder and impulsive personality disorder. This type of disorder may be related to genetic factors, childhood trauma, abnormal brain function, and other factors, usually manifested as symptoms such as emotional loss of control, self harm, and fear of being abandoned.

1. Genetic factors
Emotional instability personality disorder has familial clustering, and if there is a similar medical history in direct relatives, the probability of developing the disease will significantly increase. Research has found that this disorder is associated with polymorphisms in the serotonin transporter gene, and patients with this condition have weaker emotional regulation circuits in their brains, making them more susceptible to overreaction to external stimuli. At present, there is no targeted gene therapy method, mainly improving symptoms through psychological therapy.
2. Childhood trauma
Experiences of physical abuse, emotional neglect, or sexual assault during childhood are important triggers that can lead to abnormal development of the prefrontal cortex and amygdala, affecting emotional management abilities. Patients often suffer from post-traumatic stress disorder, characterized by a desire and fear for intimate relationships. Dialectical behavior therapy can help patients rebuild their sense of security and interpersonal trust.
3. Abnormal brain function
Neuroimaging shows abnormal activity in the anterior cingulate cortex and insula, which are responsible for emotional assessment and impulse control. Functional magnetic resonance imaging shows that patients have overactivation of the amygdala during emotional tasks, while the prefrontal cortex has insufficient inhibitory function. Transcranial magnetic stimulation and other physical therapies can regulate the activity of related brain regions.

4. Social and psychological factors
Long term exposure to high-pressure environments or negative interpersonal relationships can exacerbate symptoms, especially repeated experiences of being denied or abandoned. Patients often lack effective problem-solving skills and are prone to extreme coping strategies such as self harm when faced with stress. Group psychotherapy can help learn adaptive social skills.
5. Comorbidity
This disorder is often comorbid with depression, anxiety, substance abuse, etc., and about 60% of patients have recurrent self injurious behavior. Comorbidity can exacerbate emotional fluctuations and increase the difficulty of treatment. The combination therapy of mood stabilizers such as quetiapine tablets and lamotrigine tablets is commonly used in clinical practice, but the dosage must be strictly adjusted according to medical advice. Patients with emotionally unstable personality disorders need to establish a regular schedule, ensure adequate sleep, and avoid alcohol and caffeine intake. Engaging in 3-5 aerobic exercises such as brisk walking, swimming, etc. per week can help stabilize emotions. Family members should learn nonviolent communication skills, avoid critical language, and seek medical attention immediately when patients have thoughts of self harm. Suggest keeping an emotional diary to identify triggering factors and gradually cultivate self-regulation abilities such as mindfulness meditation.

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