What does creatinine above 100 mean

A creatinine value exceeding 100 μ mol/L may indicate mild renal dysfunction, mainly related to physiological factors, decreased glomerular filtration rate, chronic kidney disease, drug effects, and dehydration.

1. Physiological factors:

Intense exercise or a high protein diet may cause a temporary increase in creatinine. The creatinine produced by muscle metabolism is excreted through the kidneys. When muscle activity increases or protein intake is excessive, the creatinine concentration in the blood may exceed 100 μ mol/L. This type of situation usually does not require special treatment. After adjusting the diet structure and taking appropriate rest, the indicators can return to normal.

2. Decreased glomerular filtration rate: In the early stages of renal dysfunction, glomerular filtration function decreases, leading to reduced creatinine excretion. At this time, there may be symptoms such as increased nocturia and mild edema, which need to be further evaluated through urine microalbumin testing. Improving lifestyle habits such as controlling blood pressure and blood sugar, and limiting salt intake can help delay the deterioration of kidney function.

3. Chronic kidney disease:

Persistent excess creatinine may be the manifestation of chronic kidney disease, which is common in hypertensive kidney disease or diabetes kidney disease. These patients often have problems such as anemia and electrolyte imbalance, and the pathological type needs to be determined through renal biopsy. Treatment includes the use of angiotensin-converting enzyme inhibitors to control progression, and in severe cases, dialysis preparation may be necessary.

4. Drug effects:

Some antibiotics, nonsteroidal anti-inflammatory drugs, or chemotherapy drugs have nephrotoxicity and may cause an increase in creatinine levels. During the use of these medications, regular monitoring of kidney function is necessary, and medication plans may be adjusted if necessary. Common nephrotoxic drugs include gentamicin, ibuprofen, etc. After discontinuation, creatinine levels can gradually recover.

5. Dehydration state: When excessive loss of body fluids leads to blood concentration, the creatinine detection value may falsely increase. Severe diarrhea, hot work, or insufficient drinking water can all cause this condition, usually accompanied by symptoms such as decreased urine output and thirst. After timely hydration and follow-up examination, creatinine levels often fall back to the normal range.

found that elevated creatinine levels should be avoided through vigorous exercise and a high purine diet, and daily water intake should be maintained at around 2000 milliliters. It is recommended to regularly review the three aspects of renal function and observe the trend of changes in indicators. In case of continuous foam urine, lower limb edema or abnormal blood pressure, special examinations such as quantitative urine protein and kidney B ultrasound should be carried out in the nephrology department as soon as possible. Pay attention to monitoring blood pressure and blood sugar in daily life, avoid abusing nephrotoxic drugs, and supplement high-quality protein in moderation but not exceeding 0.8 grams per kilogram of body weight.