What does a high creatine kinase isoenzyme indicate

Elevated levels of creatine kinase isoenzyme usually indicate myocardial, skeletal muscle, or brain tissue damage, mainly related to acute myocardial infarction, muscle disease, vigorous exercise, brain injury, drug factors, and other reasons.

1. Acute myocardial infarction:

Creatine kinase isoenzyme CK-MB is a myocardial specific marker, and significant elevation is common in acute myocardial infarction. The release of myocardial cells begins 4-6 hours after ischemic necrosis and reaches its peak at 24 hours, which may be accompanied by chest pain and ST segment elevation on electrocardiogram. Immediate coronary angiography is required to assess vascular occlusion, and if necessary, stent implantation or thrombolytic therapy should be performed.

2. Muscle diseases:

Muscle diseases such as polymyositis and rhabdomyolysis can lead to an increase in CK-MM subtypes. After muscle fiber destruction, a large amount of enzyme bodies are released, which may be accompanied by muscle weakness, muscle pain, and darkened urine color. Further electromyography and muscle biopsy are required. Mild symptoms can be relieved through rest and fluid replacement, while severe cases require plasma exchange therapy. 3. Intense exercise: Within 48 hours after high-intensity anaerobic exercise, there may be a temporary increase in CK-MM, especially during marathons, strength training, etc. Muscle micro injury leads to enzyme release, usually without pathological significance, accompanied by muscle soreness. It is recommended to have a follow-up examination after 72 hours, during which protein and electrolytes should be supplemented to promote repair.

4. Brain injury:

CK-BB isoenzymes in brain tissue may infiltrate the bloodstream during stroke and traumatic brain injury, often accompanied by headaches and consciousness disorders. It is necessary to clarify the nature of the lesion in combination with head CT. Hemorrhagic stroke requires antihypertensive treatment, and ischemic stroke requires evaluation of thrombolysis indications.

5. Drug factors:

Statins and lipid-lowering drugs may cause drug-induced myositis, leading to an increase in CK, while drugs such as beta blockers and glucocorticoids may also interfere with the results. Usually accompanied by muscle tenderness, it can recover 2-4 weeks after discontinuation of medication. Regular monitoring of liver function and creatine kinase levels is required during medication.

It was found that an increase in creatine kinase isoenzyme should be avoided through vigorous exercise, and a daily intake of 2000 milliliters of water should be ensured to promote metabolism. Choose low-fat and high protein foods such as chicken breast and fish for diet, and supplement with vitamin D and coenzyme Q10. It is recommended that middle-aged and elderly people have their myocardial enzyme spectrum rechecked every 3 months, and those with a family history of coronary heart disease need to undergo an additional exercise stress test. Pregnant women with elevated CK-MB should rule out perinatal cardiomyopathy, and pediatric patients should be differentiated from hereditary diseases such as progressive muscular dystrophy.