What causes high creatinine index

Elevated creatinine index is usually caused by factors such as abnormal kidney function, enhanced muscle metabolism, drug effects, dehydration, or urinary tract obstruction, and requires specific examination to determine the cause.

1. Kidney disease:

Chronic nephritis, diabetes nephropathy and other renal parenchymal diseases will lead to the decline of glomerular filtration rate and the obstruction of creatinine excretion. In the early stages, it may only manifest as an increase in urinary microalbumin, and as the condition progresses, the blood creatinine level gradually increases. Diagnosis should be confirmed through urine routine, renal ultrasound and other examinations, and renal biopsy should be performed if necessary.

2. Abnormal muscle metabolism:

During rhabdomyolysis, intense exercise, or muscle trauma, a large amount of myoglobin is released into the bloodstream and metabolized by the kidneys to creatinine. This type of situation is often accompanied by a significant increase in creatine kinase and a sauce colored urine. Timely fluid replacement and alkalization of urine can prevent acute kidney injury.

3. Drug factors:

Long term use of nonsteroidal anti-inflammatory drugs, aminoglycoside antibiotics, or chemotherapy drugs may cause interstitial damage to the renal tubules. Some antihypertensive drugs, such as angiotensin-converting enzyme inhibitors, can temporarily increase creatinine levels. Regular monitoring of renal function indicators is required during medication.

4. Fluid insufficiency: When severe diarrhea, burns, or insufficient drinking water lead to a decrease in effective circulating blood volume, inadequate renal perfusion can cause creatinine retention. This situation is mostly temporary, and correcting dehydration can restore normal indicators. The elderly population is more prone to pre renal creatinine elevation caused by orthostatic hypotension.

5. Urinary tract obstruction:

Prostate hyperplasia, urinary tract stones, or tumor compression may cause bilateral urinary tract obstruction, leading to obstructive kidney disease. Patients often experience symptoms such as difficulty urinating and pain in the kidney area. After the obstruction is relieved, creatinine levels can gradually decrease.

found that elevated creatinine levels should be limited to a high protein diet, with daily protein intake controlled at 0.6-0.8 grams per kilogram of body weight, and priority given to high-quality protein such as eggs and fish. Maintain a daily water intake of at least 2000 milliliters and avoid intense exercise that exacerbates muscle breakdown. Patients with combined hypertension need to control their blood pressure below 130/80mmHg, and regularly check their urine routine, renal function, and renal ultrasound. If creatinine continues to exceed 1.5 times the normal value or is accompanied by symptoms such as edema and nausea, timely medical attention should be sought from the nephrology department.