What are the hazards of pyruvic acid above 100

Pyruvate higher than 100 μ mol/L may indicate abnormal metabolism. The main hazards include increased risk of lactic acid poisoning, energy metabolism disorder, increased liver and kidney burden, nervous system damage and increased risk of complications of diabetes.

1. Lactic acidosis:

Acetoacetate is an intermediate product of glycolysis metabolism, and its accumulation can lead to an increase in lactate production. When the concentration of pyruvic acid in the blood continues to exceed 100 μ mol/L, it may cause metabolic acidosis, manifested as symptoms such as deep and fast breathing, nausea and vomiting, and in severe cases, can lead to consciousness disorders. This condition is common in mitochondrial dysfunction or vitamin B1 deficiency.

2. Energy metabolism disorders:

Accumulation of pyruvate can inhibit the activity of key enzymes in the tricarboxylic acid cycle, affecting ATP production efficiency. Patients may experience persistent fatigue, muscle weakness, and other manifestations of insufficient energy supply, which may lead to sarcopenia in the long term. This situation is closely related to metabolic diseases such as diabetes and chronic alcoholism.

3. Increased burden on liver and kidney:

The liver is the main organ for pyruvate metabolism, and long-term high concentrations of pyruvate can lead to mitochondrial damage in liver cells, manifested as elevated transaminase levels. The kidneys are excretory organs, and excessive pyruvate may cause vacuolar degeneration of renal tubular epithelial cells. Laboratory tests have shown an increase in urinary alpha 1-microglobulin.

4. Neurological injury:

Acetoacetate can pass through the blood-brain barrier, and its metabolic abnormalities can interfere with neurotransmitter synthesis. Symptoms such as memory loss and peripheral neuropathy may occur clinically, and developmental delay may occur in infants and young children. This condition is common in hereditary pyruvate dehydrogenase complex deficiency.

5. Complications of diabetes:

The increase of pyruvate in diabetes patients indicates that insulin resistance is aggravated. High pyruvate level will promote the formation of advanced glycation end products and accelerate the progress of microvascular complications such as diabetes retinopathy and nephropathy. When monitoring, it is necessary to comprehensively evaluate indicators such as glycated hemoglobin.

It is recommended to regularly monitor blood sugar and liver and kidney function, and maintain a daily water intake of over 2000ml to promote the excretion of metabolic waste. Choose low glycemic index foods such as oats and buckwheat for diet, and avoid alcohol intake. Moderate aerobic exercise such as brisk walking and swimming can improve mitochondrial function, but it is necessary to avoid excessive exercise that can induce lactate accumulation. When experiencing unexplained fatigue or shortness of breath, seek medical attention promptly for arterial blood gas analysis.