What are the hazards of high urea nitrogen to the human body

Elevated urea nitrogen levels may indicate abnormal kidney function or protein metabolism disorders. Long term lack of intervention may lead to nausea and vomiting, electrolyte imbalance, increased cardiovascular burden, and other hazards. Urea nitrogen is the final product of protein metabolism, mainly excreted through the kidneys. When the value slightly increases, it may only manifest as fatigue or decreased appetite, commonly seen in physiological fluctuations after high protein diet, dehydration, or intense exercise. If it continues to exceed 9.5 mmol/L, it may be accompanied by a synchronous increase in blood creatinine. At this time, the renal filtration function has been impaired, and the accumulation of toxins in the body can cause irritation of the gastrointestinal mucosa, leading to symptoms such as repeated nausea and morning dry vomiting. Some patients may experience electrolyte imbalances such as dry and flaky skin and nighttime cramps. When the value exceeds 20mmol/L and reaches the stage of uremia, it may induce pulmonary edema or pericardial effusion. High concentrations of urea nitrogen can alter platelet function and increase the risk of gastrointestinal bleeding. For patients with pre-existing hypertension or coronary heart disease, it may accelerate the process of vascular calcification. Abnormal urea nitrogen levels in pregnant women may affect fetal development and require special attention.

Daily protein intake should be controlled at 0.6-0.8 grams per kilogram of body weight, with priority given to high-quality proteins such as eggs and fish. Pay attention to monitoring changes in blood pressure and urine output, and avoid using nephrotoxic drugs. It is recommended to recheck renal function, routine urine test and renal ultrasound every 3-6 months. diabetes patients need to check urinary microalbumin at the same time. When severe edema or confusion occurs, seek medical attention immediately.