Reasons and treatment methods for high levels of pyruvic acid

High pyruvate may be caused by strenuous exercise, vitamin B1 deficiency, diabetes ketoacidosis, abnormal liver function, genetic metabolic diseases, etc. It can be improved by adjusting exercise intensity, supplementing vitamin B1, controlling blood sugar, liver protection treatment, metabolic intervention, etc.

1. Intense exercise:

High intensity anaerobic exercise can cause muscles to produce a large amount of pyruvate, which temporarily increases when it exceeds the body's metabolic capacity. It is recommended to supplement carbohydrates after exercise, avoid fasting exercise, and gradually increase the intensity of exercise.

2. Vitamin B1 deficiency:

Vitamin B1 is a key coenzyme in pyruvate metabolism, and long-term alcohol abuse and gastrointestinal absorption disorders can lead to deficiency. Take thiamine tablets orally and consume more foods rich in B1, such as whole grains, lean meat, and legumes.

3. diabetes ketosis:

When insulin is insufficient, fat decomposition produces a large number of ketones, accompanied by thirst, polyuria and other symptoms. Blood glucose needs to be monitored, insulin control should be used, and if necessary, intravenous fluid replacement should be administered to correct acidosis.

4. Abnormal liver function:

Diseases such as hepatitis and cirrhosis affect lactate circulation, leading to the accumulation of pyruvate. It is necessary to improve liver function tests, use liver protective drugs such as compound glycyrrhizin and silibinin, and limit protein intake.

5. Genetic metabolic diseases: Rare diseases such as

pyruvate carboxylase deficiency can lead to persistent elevation, often accompanied by developmental delay. Diagnosed through genetic testing and treated with special nutritional support such as ketogenic diet and levocarnitine.

It is necessary to maintain a regular daily routine and avoid staying up late and excessive fatigue. Add foods rich in B vitamins such as brown rice and oats to the diet, and limit high-fat diets. Moderate aerobic exercise such as brisk walking and swimming can promote pyruvate metabolism, but it is necessary to avoid testing indicators immediately after intense exercise. If there are long-term abnormalities or accompanied by symptoms such as weight loss and nausea, metabolic diseases should be promptly investigated.