Thyroid stimulating hormone TSH 6.25mIU/L is mildly elevated, and in most cases indicates subclinical hypothyroidism. Abnormal TSH may be related to factors such as insufficient iodine intake, autoimmune thyroiditis, drug effects, pituitary lesions, or physiological changes during pregnancy.

1. Insufficient iodine intake:
Long term iodine deficiency can lead to insufficient synthesis of thyroid hormones, feedback causing TSH elevation. Daily supplementation can be achieved by consuming iodine rich foods such as iodized salt and kelp. In areas with severe iodine deficiency, iodine intervention should be carried out under the guidance of a doctor.
2. Autoimmune thyroiditis:
Hashimoto's thyroiditis is a common cause, and patients' anti thyroid peroxidase antibodies will attack thyroid tissue. The initial manifestation is a mild increase in TSH, which may be accompanied by symptoms such as neck swelling and fatigue. Diagnosis requires a combination of thyroid ultrasound and antibody testing.
3. Drug effects:

Lithium preparations, amiodarone, and other drugs may interfere with thyroid function. During the use of such drugs, TSH elevation may occur, and the necessity of adjusting the drug dosage needs to be evaluated. Usually, it can gradually recover after discontinuation of the medication.
4. Pituitary lesions:
Pituitary tumors or inflammation may lead to abnormal TSH secretion, but such conditions are often accompanied by other pituitary hormone disorders, such as visual impairment, headache, etc., and require MRI examination to confirm the diagnosis.
5. Changes during pregnancy:
In early pregnancy, due to stimulation by chorionic gonadotropin, there may be a brief decrease in TSH, and in the middle and later stages, some pregnant women may experience a reactive increase. The TSH control standards during pregnancy are different from those of the general population and need to be evaluated based on gestational week specific reference values.

It is recommended that individuals with mild TSH elevation have their thyroid function rechecked every 3-6 months, with a focus on monitoring changes in free T4 levels. Pay attention to maintaining a regular daily routine and avoid excessive fatigue; Eating a moderate amount of selenium rich foods such as Brazil nuts and oysters can help with thyroid hormone metabolism; Pay attention to keeping the neck warm in winter and reduce the impact of cold stimulation on the thyroid gland. If there are obvious symptoms of hypothyroidism such as fear of cold, weight gain, and memory loss, or if TSH continues to exceed 10mIU/L, it is necessary to seek timely evaluation of the necessity of alternative treatment at the endocrinology department.
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