Is prothrombin time 17.5 severe

The prothrombin time of 17.5 seconds is mildly prolonged and in most cases not severe. Prolonged prothrombin time may be related to factors such as vitamin K deficiency, warfarin anticoagulant therapy, chronic liver disease, congenital coagulation factor deficiency, disseminated intravascular coagulation, etc.

1. Vitamin K deficiency:

Vitamin K is an essential substance for the synthesis of coagulation factors II, VII, IX, and X. Insufficient intake or absorption disorders can lead to prolonged prothrombin time. Green leafy vegetables, animal liver and other foods can supplement vitamin K. In severe cases of deficiency, it is necessary to supplement vitamin K preparations under the guidance of a doctor.

2. Effects of anticoagulant drugs:

Anticoagulants such as warfarin prolong prothrombin time by inhibiting vitamin K-dependent coagulation factor synthesis. Regular monitoring of INR values is required during medication, and dosage should be adjusted based on the results to avoid the risk of bleeding.

3. Chronic liver disease:

The liver is the main site of coagulation factor synthesis, and diseases such as cirrhosis can lead to a decrease in coagulation factor synthesis. Patients may experience symptoms such as jaundice and ascites, and require targeted treatment for the underlying disease and supplementation of coagulation factors.

4. Congenital coagulation abnormalities:

Genetic deficiencies in coagulation factors II, V, VII, and X can lead to prolonged prothrombin time. These patients often have a family history of bleeding and need to be diagnosed through coagulation factor activity testing. If necessary, plasma or specific coagulation factors may be administered.

5. Diffuse intravascular coagulation: During DIC, excessive consumption of coagulation factors can lead to prolonged prothrombin time, often accompanied by thrombocytopenia and decreased fibrinogen. Urgent treatment of the primary disease is required, along with supplementation of coagulation factors and platelets. When the prothrombin time is mildly prolonged, it is recommended to increase the intake of foods rich in vitamin K, such as spinach, broccoli, pig liver, etc. Avoid strenuous exercise and trauma, use a soft bristled toothbrush to reduce the risk of gum bleeding. Regularly check coagulation function, and seek medical attention promptly if there are abnormal bleeding symptoms such as skin bruising or nosebleeds. Long term use of anticoagulant drugs requires strict adherence to medical advice and cannot be self adjusted in dosage. Patients with abnormal liver function need to limit alcohol intake and ensure sufficient sleep to reduce liver burden.