Is prothrombin time 14.6 normal

Whether the prothrombin time of 14.6 seconds is normal needs to be determined by combining the detection reagent and laboratory reference range. The reference value for most laboratories is 11-14 seconds, and if the detection limit is 14 seconds, it is slightly higher; If the upper limit is 15 seconds, it is within the normal range. Prolonged prothrombin time may be associated with vitamin K deficiency, warfarin therapy, liver disease, or coagulation factor deficiency. Prothrombin time is an important indicator for evaluating the function of exogenous coagulation pathways, mainly reflecting the activity of coagulation factors II, V, VII, and X. When the result is within 14.6 seconds, priority should be given to confirming the international sensitivity index and localized standard range of the reagents used. When some laboratories use thromboelastography for detection, the upper limit of normal values can be extended to 15 seconds. At this point, a slight increase may be related to non pathological factors such as fluctuations in recent intake of foods rich in vitamin K and deviations in the proportion of sodium citrate during specimen collection. It is recommended to maintain an empty stomach for 8 hours before re examination to avoid vigorous exercise affecting the accuracy of the test. If the laboratory standard upper limit is 14 seconds and multiple test results remain consistently high, pathological factors need to be considered. Mild prolongation is common in patients who take warfarin for a long time, and the drug exerts anticoagulant effects by inhibiting vitamin K-dependent coagulation factor synthesis. When liver parenchymal injury occurs, the ability of the liver to synthesize coagulation factors decreases, which may be accompanied by thrombocytopenia and fibrinogen reduction. Genetic diseases such as congenital factor VII deficiency can also lead to isolated prothrombin time prolongation, which often presents as abnormalities from a young age and is accompanied by a tendency to bleed.

It is recommended to bring a complete coagulation function report with INR value to the hematology or cardiovascular department for consultation. Doctors will conduct a comprehensive evaluation based on medication history, family history, and other coagulation indicators, and if necessary, perform coagulation factor activity testing or genetic testing. Daily attention should be paid to observing abnormal bleeding such as skin bruising and gum bleeding, and using a soft bristled toothbrush to reduce mucosal damage. Controlling the intake of dark green vegetables can stabilize the anticoagulant effect of warfarin, but complete fasting is not necessary.