Is prothrombin time 14.2 severe

Prothrombin time of 14.2 seconds is generally considered a mild abnormality and should be judged based on specific clinical conditions. The main influencing factors include vitamin K deficiency, use of anticoagulants such as warfarin, chronic liver disease, genetic coagulation factor deficiency, disseminated intravascular coagulation, etc.

1. Vitamin K deficiency:

Vitamin K is an essential cofactor for the synthesis of coagulation factors II, VII, IX, and X. Insufficient intake, such as long-term fasting, absorption disorders, biliary diseases, or dysbiosis of the gut microbiota, can all lead to deficiency. Mild deficiency can be improved by increasing intake of green leafy vegetables or taking oral vitamin K supplements, while severe cases require intramuscular injection of vitamin K.

2. anticoagulant effects:

Warfarin interferes with coagulation factor synthesis by inhibiting vitamin K epoxide reductase. Regular monitoring of INR values is required during medication, and if the corresponding INR is between 2-3 within 14.2 seconds, it falls within the therapeutic range. Attention should be paid to interactions with other medications such as antibiotics or foods such as spinach.

3. Chronic liver disease:

Cirrhotic patients have decreased liver synthesis function, manifested by reduced coagulation factors and decreased platelets. May be accompanied by symptoms such as jaundice and ascites. Improvement needs to be achieved through liver protection treatment, infusion of fresh frozen plasma, and screening for complications related to portal hypertension.

4. Genetic coagulation abnormalities:

Genetic diseases such as coagulation factor II, V, VII, and X deficiencies can lead to isolated PT prolongation. The type needs to be determined through coagulation factor activity testing and genetic diagnosis, and plasma or specific coagulation factor concentrates can be administered during bleeding.

5. Diffuse intravascular coagulation:

DIC is a critical condition, accompanied by prolonged PT, thrombocytopenia, fibrinogen reduction, and elevated D-dimer levels. Commonly seen in severe infections, malignant tumors, or obstetric emergencies, immediate treatment of the primary disease and supplementation of clotting substances are required.

It is recommended to regularly review coagulation function and observe bleeding tendencies such as gum bleeding and subcutaneous bruising. Avoid vigorous exercise and trauma in daily life, and use aspirin and other drugs that affect platelet function with caution. Diet can moderately increase broccoli and spinach rich in vitamin K, but those taking warfarin need to maintain a stable intake. If symptoms of intracranial hemorrhage such as vomiting blood, black stool, or headache and vomiting occur, seek medical attention immediately.