Is prothrombin activity 150 normal

A prothrombin activity of 150% belongs to the high range, and it is recommended to evaluate it comprehensively in combination with other coagulation indicators. Abnormal prothrombin activity may be related to factors such as excessive intake of vitamin K, improper use of warfarin, cholestatic liver disease, genetic coagulation factor abnormalities, and early disseminated intravascular coagulation.

1. Excessive intake of vitamin K:

Vitamin K is an essential nutrient for the synthesis of clotting factors. Excessive intake of foods or supplements rich in vitamin K, such as animal liver and spinach, can promote the synthesis of clotting factors II, VII, IX, and X, leading to an increase in prothrombin activity. Long term elevated levels may increase the risk of thrombosis, and dietary adjustments and monitoring of coagulation function are necessary.

2. Improper use of warfarin:

anticoagulant drug warfarin works by inhibiting vitamin K-dependent coagulation factors. If the dosage is insufficient or the medication is suddenly stopped, it will cause a rebound in coagulation factor synthesis, manifested as a significant increase in prothrombin activity in the short term. This situation requires adjustment of anticoagulant regimen under the guidance of a doctor to avoid thrombosis or bleeding events.

3. Cholestasis related liver disease:

Diseases such as biliary obstruction or primary biliary cirrhosis can affect the absorption of fat soluble vitamin K. In the early stages, due to compensatory mechanisms, there may be a temporary increase in prothrombin activity, accompanied by symptoms such as skin itching and jaundice. As the condition progresses, it will eventually turn into a decrease in coagulation function, which needs to be diagnosed through imaging examination and liver function assessment.

4. Hereditary coagulation factor abnormalities:

Genetic diseases such as coagulation factor VLeiden mutations or prothrombin G20210A gene mutations can lead to excessive activation of coagulation factors, resulting in sustained high prothrombin activity. These patients often have a family history of venous thrombosis and need to be diagnosed through genetic testing. If necessary, preventive anticoagulant therapy should be administered.

5. Early disseminated intravascular coagulation:

Early disseminated intravascular coagulation (DIC) temporarily activates the coagulation system due to the release of large amounts of procoagulant substances, manifested as increased prothrombin activity and elevated D-dimer levels. As the condition progresses, the value of coagulation factors will rapidly decrease after consumption. Dynamically monitor indicators such as platelets and fibrinogen to promptly address the primary cause. When elevated prothrombin activity is found, it is recommended to avoid vigorous exercise and trauma, and reduce high-fat diet intake. Moderate increase in drinking water can promote blood circulation, and regular check ups of coagulation parameters, D-dimer, and other indicators can be conducted. If symptoms such as lower limb swelling and chest pain occur simultaneously, seek medical attention immediately to check for blood clots. Pregnant women, postoperative patients and other high-risk groups should strengthen monitoring frequency and intervene under the guidance of hematology department if necessary.