Is it important that only fibrinogen is low

In most cases, there is no need to worry excessively about low levels of fibrinogen, which may be caused by physiological fluctuations, mild infections, drug effects, decreased liver synthesis function, or genetic factors.

1. Physiological fluctuations:

Fibrinogen levels exhibit diurnal variations and individual differences, and may temporarily decrease during menstruation and mid to late pregnancy in women. When the detection value of healthy individuals is slightly lower than the lower limit of the reference range, if there is no bleeding tendency, it usually belongs to normal physiological variation.

2. Mild infection:

Acute infections such as viral colds may lead to a decrease in fibrinogen depletion, often accompanied by symptoms such as fever and fatigue. Follow up 1-2 weeks after infection control, and most indicators can recover on their own.

3. Drug effects:

Long term use of anticoagulant drugs such as aspirin and heparin, or thrombolytic drugs such as defibrase, can interfere with fibrinogen metabolism. It is necessary to judge based on medication history and adjust the medication plan under the guidance of a doctor if necessary.

4. Liver disease:

Patients with chronic hepatitis and cirrhosis may experience sustained low levels of fibrinogen due to impaired liver synthesis function, usually accompanied by abnormal indicators such as decreased albumin and prolonged prothrombin time.

5. Genetic factors:

Congenital hypoalbuminemia is a rare genetic disease, and patients have a tendency to bleed from a young age, which needs to be diagnosed through genetic testing. Most patients can meet their daily coagulation needs by maintaining fibrinogen levels between 0.8-1.5g/L.

It is recommended to avoid vigorous exercise and trauma in daily life, increase intake of foods rich in vitamin K such as spinach and broccoli, and regularly monitor coagulation function. If there is repeated nosebleeds, gum bleeding, or skin bruising, or if fibrinogen remains below 0.8g/L, pathological factors such as liver disease and disseminated intravascular coagulation should be promptly investigated. Pregnant women and preoperative patients should undergo coagulation assessment in advance and supplement fibrinogen preparations if necessary.