The treatment of paranoid ideation requires a combination of psychological intervention and medication control. Commonly used medications include risperidone, olanzapine, quetiapine, aripiprazole, and chlorpromazine. Paranoia is a spectrum disorder of schizophrenia, and patients need to develop personalized treatment plans under the guidance of a psychiatrist.

1. Risperidone
Risperidone is an atypical antipsychotic drug that improves delusional symptoms by regulating dopamine and serotonin receptors. Suitable for patients with paranoid ideation accompanied by agitated behavior, it can alleviate hostile emotions and feelings of persecution. Common adverse reactions include extrapyramidal reactions and elevated prolactin levels, and long-term use requires monitoring of metabolic indicators.
2. Olanzapine
Olanzapine has an improvement effect on both positive and negative symptoms, and is suitable for patients with paranoid ideation accompanied by emotional apathy. This drug has a strong sedative effect, which may cause weight gain and blood sugar rise. diabetes patients should be cautious when using it. During treatment, liver function and blood lipid levels should be regularly evaluated.
3. Quetiapine
Quetiapine has good tolerance to elderly patients with paranoid ideation and can improve their perception of victimization and sleep disorders. Drug metabolism is fast, and it needs to be administered in divided doses to maintain blood drug concentration. Common side effects include dizziness and orthostatic hypotension, and patients with cardiovascular disease need to adjust the dosage.

4. Aripiprazole
Aripiprazole, as a dopamine partial agonist, has a low probability of triggering extrapyramidal reactions and is suitable for patients who require long-term maintenance treatment. The medication has a minor impact on cognitive function, but may cause anxiety and insomnia. Early use of the medication requires close observation of symptom changes.
5. Clozapine
Chlorpromazine is commonly used for refractory paranoid ideation and may be effective for patients who are unresponsive to traditional medications. Due to the possibility of causing granulocyte deficiency, blood routine should be monitored weekly during medication. The sedative effect of this drug is significant, and caution should be exercised when using sedatives in combination to avoid the risk of respiratory depression.

In addition to standardized medication, it is recommended that patients with paranoid ideation cooperate with cognitive-behavioral therapy to correct distorted cognition, and family support is crucial for recovery. Maintaining a regular schedule and moderate exercise can help alleviate symptoms and avoid consuming irritating substances such as alcohol and caffeine. Regular follow-up visits are required to evaluate the efficacy and side effects. Medication adjustments must strictly follow medical advice and dosage cannot be increased or decreased on one's own. During the stable period of the condition, social skills training can be attempted to gradually restore social function.
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