How should male and female adrenal gland sexual dysfunction be diagnosed?

Female pseudohermaphroditism can also be seen as a result of the presence of androgens from the placenta during pregnancy. This type of androgen can come from ovarian tumors caused by masculinization, or from maternal treatment with corticosteroids or synthetic progesterone during pregnancy.is a sexual abnormality caused by excessive adrenal androgens, leading to virilism in females and males.What is adrenal sexual dysfunction?

Adrenal sexual dysfunction is caused by excessive levels of adrenal androgens, leading to premature puberty in females and males. However, it is difficult to determine the clinical condition of adult males. This symptom is pseudohermaphroditism in females, characterized by thickening of the adrenal cortex. Creechio was recorded in 1866, but the detailed description of this disease was first used in 1905 by Seueira and 1912 by Gallais under the name adrenogenic syndrome. The current term 'this disease' refers to the issue of masculinization in both males and females.

[Diagnosis]

Diagnosing this disease is not easy. Sometimes, after thorough, meticulous, and time-consuming examination, no conclusion can be drawn. But without a correct diagnosis, reasonable treatment is also impossible. Firstly, determine which type of patients require a thorough examination. Generally speaking, those with obvious clinical manifestations require thorough examination. Of course, it may be necessary to check for time; On the other hand, if there are symptoms in childhood or sudden onset in adulthood, it should be suspected as a tumor.

1. In females: it is a female pseudohermaphroditism, which can be diagnosed based on the following examinations:

(1) Microscopic examination of the cell nucleus, showing positive chromatin. Chromosome count, sex chromosome karyotype is xx type.

(2) Check the urogenital sinus and see the presence of the vagina. If the vagina is examined with a urethroscope, the presence of the uterus can be seen. A catheter can be inserted through the cervix for uterine and imaging purposes.

(3) Biochemical test shows excessive excretion of steroids in urine.

Female pseudohermaphroditism can also be seen as a result of maternal androgens transmitted through the placenta during pregnancy. This type of androgen can come from acting on it or from maternal treatment with corticosteroids or synthetic progesterone during pregnancy.

2. In males, the nuclear chromatin is negative, and their genotype is xy. There is an increase in the excretion of steroid substances in the urine, such as in females.

3. Differential diagnosis between hyperplasia and tumor: often difficult. A large tumor can be palpable, and adrenal hyperplasia on both sides can also be palpable at birth. Inhibition tests on the hypothalamus may be helpful. The determination of urinary sterols is helpful for the diagnosis of cancer, hyperplasia, or tumors. The biggest challenge is that the excretion of 11 oxos in urine can be normal during tumor formation. Fortunately, there is always one of the sterols whose value increases. X-ray examination can sometimes be helpful. If the tumor cannot be ruled out through multiple examinations, surgical exploration is necessary.