Dapoxetine usually takes effect within 1-3 hours after taking, and the specific time is affected by individual differences, fasting status, drug dosage, and other factors. Dapoxetine is a selective serotonin reuptake inhibitor primarily used for the treatment of premature ejaculation. After entering the body, drugs need to be absorbed through the gastrointestinal tract and enter the bloodstream, and then act on the central nervous system through the blood-brain barrier. The absorption rate is faster on an empty stomach, and if taken with high-fat foods, it may delay the efficacy of the medication. Under standard dosage, most patients can perceive the effect within about 1 hour, while some sensitive individuals may experience the effect within 30 minutes, while those with slower metabolism need to wait for more than 3 hours. The peak concentration of drugs usually reaches 1.4-2 hours after administration, at which point the effect is most significant.
In rare cases, there may be an abnormal delay in the onset time. For example, taking acid suppressants at the same time can lower the gastric acid environment and affect absorption. People with liver dysfunction may have a slower metabolic rate, and overweight patients may experience a slow increase in blood drug concentration due to an increase in distribution volume. These special circumstances may cause the efficacy to be delayed until 4-5 hours or require dosage adjustments to achieve the expected effect. Clinical observations have shown that some patients may experience cumulative effects after repeated medication, and the onset time may be earlier than when taken for the first time.
It is recommended to take dapoxetine on an empty stomach 1-2 hours before expected sexual activity and avoid taking it with grapefruit juice or alcohol. During medication, it is necessary to observe individual reaction patterns, and seek medical attention promptly if severe headaches or palpitations occur. Regular sleep and pelvic floor muscle exercise can assist in improving premature ejaculation symptoms, and long-term treatment requires a combination of psychological counseling and behavioral therapy.
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