Paranoia may be caused by genetic factors, abnormal brain structure, psychological trauma, schizophrenia, substance abuse, and other reasons. Paranoia is a type of delusional disorder in which patients often exhibit unfounded beliefs that they are being persecuted, and can be intervened through medication, psychological therapy, and other methods.

1. Genetic factors [SEP]: Having a history of mental illness in a family may increase the risk of developing the disease. Some patients have specific genetic variations that affect neurotransmitter balance. The incidence of illness among relatives is higher than that of the general population, but it is not absolutely hereditary. It is recommended that individuals with a family history undergo regular mental health assessments to detect abnormal symptoms early on. Maintaining a regular daily routine can help reduce the likelihood of developing the disease.
2. Abnormal brain structure
Dysfunction of the temporal lobe or limbic system of the brain may lead to abnormal perception and processing. Neuroimaging examination shows that some patients have abnormal brain activity in certain regions. This physiological change may affect the ability to verify reality. Avoiding head trauma and controlling cerebrovascular risk factors such as hypertension are helpful for prevention. If there is persistent abnormal perception, seek medical attention promptly.
3. Psychological trauma
Childhood abuse, violent experiences, and other traumas may disrupt psychological defense mechanisms. Long term exposure to high-pressure environments can exacerbate feelings of insecurity and gradually form pathological cognitive patterns. Patients with post-traumatic stress disorder are more likely to develop a sense of victimization. Establishing stable interpersonal relationships can help repair psychological damage. Progressive exposure therapy is recommended for trauma intervention.
4. About 80% of schizophrenia patients experience paranoid delusions. Overactivity of the dopamine system may lead to a decrease in realistic judgment. Often accompanied by positive symptoms such as auditory hallucinations and cognitive disorders. Early use of antipsychotic drugs such as olanzapine and risperidone can improve symptoms. Social function training can help patients recover their daily living abilities.

5. Substance abuse
Long term alcohol abuse or use of substances such as methamphetamine can damage the nervous system. Transient delusions may occur in a state of poisoning, and continued abuse can develop into chronic disorders. During withdrawal, delusional symptoms may worsen. detoxification treatment should be conducted in a professional institution, in conjunction with the use of quetiapine and other medications to control psychiatric symptoms. Symptoms can often be relieved after complete withdrawal.
Patients with paranoid ideation need to establish a regular daily routine and ensure sufficient sleep to help stabilize their emotions. Family members should avoid arguing with patients about delusional content and instead focus on their real needs. Moderate low-intensity exercise such as walking and yoga can alleviate anxiety. Pay attention to a balanced diet and limit caffeine intake. Regular follow-up visits to adjust treatment plans, combined with cognitive-behavioral therapy, can improve social functioning. If there is a tendency to self harm or injure others, seek medical attention immediately.

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