How is high uric acid in children caused

Elevated uric acid levels in children are usually caused by imbalanced dietary structure, metabolic abnormalities, drug effects, genetic factors, and weakened renal excretion function, and should be evaluated based on specific examination results.

1. Dietary factors:

A high purine diet is a common cause of elevated uric acid levels in children. Excessive intake of high purine foods such as animal organs, seafood, and thick meat soup, or long-term consumption of sugary drinks, can increase the production of uric acid, a purine metabolite, in the body. Some children prefer to eat fast food and fried foods, as these high-fat diets can inhibit uric acid excretion and further exacerbate numerical abnormalities.

2. Metabolic abnormalities:

Obese children are more likely to experience uric acid metabolism disorders. Inflammatory factors secreted by adipose tissue can interfere with purine metabolism, while insulin resistance reduces the kidney's ability to clear uric acid. These children are often accompanied by metabolic syndrome symptoms such as abnormal blood lipids and blood glucose fluctuations.

3. Drug effects:

Certain therapeutic drugs may interfere with uric acid metabolism. Diuretics such as furosemide competitively inhibit renal tubular excretion of uric acid, while chemotherapy drugs produce large amounts of purine metabolites during tumor cell breakdown. Long term use of immunosuppressant cyclosporine may also lead to uric acid retention.

4. Genetic predisposition:

Primary hyperuricemia is associated with genetic metabolic defects. Rare diseases such as Lai Shi Nain syndrome can lead to abnormal purine synthase activity, resulting in excessive uric acid production. Children with a family history of gout or kidney stones may have polymorphic changes in uric acid metabolism related genes.

5. Kidney problems:

Decreased uric acid excretion ability during renal insufficiency. Chronic nephritis, renal tubular acidosis, and other diseases can affect the function of urate transporters, leading to uric acid retention. These children often have both abnormal urine routine and elevated blood creatinine.

found that children with elevated uric acid should prioritize adjusting their diet structure, ensuring 1500-2000 milliliters of water per day to promote excretion, and limiting the intake of high fructose foods. Suggest increasing the proportion of alkaline foods such as low-fat dairy products and fresh vegetables, and moderate aerobic exercise such as swimming and cycling to control weight. If the concentration continues to exceed 420 μ mol/L or is accompanied by joint swelling and pain, it is necessary to promptly screen for genetic metabolic diseases or kidney diseases to avoid long-term high uric acid levels leading to gouty arthritis or uric acid kidney stones. Regularly check uric acid levels and monitor blood pressure, urinary protein, and other indicators. If necessary, use drugs that promote uric acid excretion or inhibit its production under the guidance of a doctor.