Can prothrombin activity level 40 be restored

Prothrombin activity of 40% can mostly be restored to normal range through standardized treatment. The main methods to improve coagulation function include supplementing vitamin K, treating liver diseases, controlling the use of anticoagulant drugs, correcting malnutrition, and treating hemorrhagic diseases.

1. Supplementing with Vitamin K:

Vitamin K is an essential substance for synthesizing clotting factors, and a deficiency can lead to a decrease in prothrombin activity. It can be supplemented by consuming dark green vegetables such as spinach and broccoli. In severe cases, intramuscular injection of vitamin K1 is necessary. Patients with chronic diarrhea or biliary obstruction should pay special attention to the problem of vitamin K absorption disorders.

2. Treatment of liver diseases:

Liver diseases such as cirrhosis and hepatitis can significantly affect the synthesis of coagulation factors. A prothrombin activity of 40% may be associated with abnormal liver function, often accompanied by symptoms such as jaundice and ascites. Liver protective drugs such as silibinin and glycyrrhetinic acid preparations are required for treatment, and artificial liver support may be necessary.

3. Adjust anticoagulant therapy:

Excessive use of anticoagulants such as warfarin can inhibit vitamin K-dependent coagulation factor synthesis. Regular monitoring of INR values is required during medication. When activity drops to 40%, consideration should be given to reducing or suspending medication, and excessive use of vitamin K antagonists may be necessary.

4. Improving Nutritional Status:

Long term protein and energy malnutrition can affect the production of coagulation factors. It is necessary to strengthen the intake of high-quality protein such as fish and soy products, while supplementing hematopoietic raw materials such as iron and folic acid. Patients with severe malnutrition may require intravenous nutritional support.

5. Treatment of hemorrhagic diseases:

Diseases such as disseminated intravascular coagulation consume a large amount of clotting factors. Reduced prothrombin activity may be accompanied by symptoms such as skin bruising and mucosal bleeding. It is necessary to treat the primary disease by infusing fresh frozen plasma to supplement coagulation factors if necessary.

It is necessary to maintain a balanced diet in daily life, with a focus on supplementing foods rich in vitamin K such as natto and animal liver. Avoid strenuous exercise and trauma, use a soft bristled toothbrush to reduce the risk of gum bleeding. Regularly check coagulation function, and limit alcohol intake for those with abnormal liver function. Persistent abnormalities in coagulation indicators should be investigated for rare causes such as genetic coagulation factor deficiency, and genetic testing should be performed if necessary. During the recovery period, avoid taking medications such as aspirin that affect platelet function.