Whether to inject growth hormone at the age of 17 depends on the condition of epiphyseal closure. It may be effective for those whose epiphyses are not closed, but the effect is limited for those who have closed. The main influencing factors include epiphyseal line status, degree of growth hormone deficiency, underlying diseases, genetic factors, and nutritional status.
1. Closure of epiphyseal plate:
Evaluating whether the epiphyseal plate line is closed through bone age slices is the primary condition. If the growth plates of the wrist, knee joint, etc. are not completely ossified, growth hormone may stimulate chondrocyte proliferation; If it is closed, the bone loses its longitudinal growth potential, and injection is ineffective at this time.
2. Degree of hormone deficiency: Adolescents diagnosed with growth hormone deficiency (GHD) are the main target population and need to be confirmed through tests such as insulin hypoglycemia test. Patients with idiopathic dwarfism should undergo strict evaluation before use, and non pathological dwarfism is not recommended for misuse.
3. Impact of underlying diseases:
hypothyroidism, chronic kidney disease, and other diseases can interfere with the efficacy of growth hormone and require priority treatment for the primary disease. Growth hormone is forbidden in tumor patients and children with diabetes, which may induce metabolic abnormalities or promote tumor recurrence.
4. Genetic potential assessment:
Parental height inheritance accounts for 70% of the determinants of height, and the target height range needs to be calculated. If the current height does not reach the lower limit of genetic potential and meets medical indications, hormone intervention should be considered.
5. Nutritional exercise coordination:
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